Multi-dimensional image reconstruction
First Claim
1. Apparatus for gamma radiation based imaging and analysis of a non-homogenous three dimensional (3D) target area having distinguishable regions therein, the apparatus comprising:
- an imaging circuit configured to obtain gamma radiation emission data from said 3D target area in the spatial dimensions and at least one other dimension in a single imaging session, to obtain one or more images; and
an image multi-dimensional analysis circuit associated with said imaging circuit for analyzing said obtained one or more images in said spatial dimensions and said at least one other dimension in order to discern patterns across said dimensions;
wherein said at least one other dimension is indicative of radiation data of at least one radiopharmaceutical in said 3D target area during said single imaging session.
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Abstract
Apparatus for radiation based imaging of a non-homogenous target area having distinguishable regions therein, comprises: an imaging unit configured to obtain radiation intensity data from a target region in the spatial dimensions and at least one other dimension, and an image four-dimension analysis unit analyzes the intensity data in the spatial dimension and said at least one other dimension in order to map the distinguishable regions. The system typically detects rates of change over time in signals from radiopharmaceuticals and uses the rates of change to identify the tissues. In a preferred embodiment, two or more radiopharmaceuticals are used, the results of one being used as a constraint on the other.
743 Citations
40 Claims
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1. Apparatus for gamma radiation based imaging and analysis of a non-homogenous three dimensional (3D) target area having distinguishable regions therein, the apparatus comprising:
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an imaging circuit configured to obtain gamma radiation emission data from said 3D target area in the spatial dimensions and at least one other dimension in a single imaging session, to obtain one or more images; and an image multi-dimensional analysis circuit associated with said imaging circuit for analyzing said obtained one or more images in said spatial dimensions and said at least one other dimension in order to discern patterns across said dimensions; wherein said at least one other dimension is indicative of radiation data of at least one radiopharmaceutical in said 3D target area during said single imaging session. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. Apparatus for gamma radiation based imaging of a non-homogenous three dimensional (3D) target area having distinguishable voxels therein, the apparatus comprising:
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an imaging circuit configured to obtain gamma radiation emission data from said 3D target area in spatial dimensions and a time dimension in a single imaging session, as one or more images; and an image multi-dimensional analysis circuit associated with said imaging circuit for analyzing said obtained one or more images in said spatial dimensions and said time dimension in order to discern at least one property, during said single imaging session, from a time profile of a radiopharmaceutical marker in at least one of said distinguishable voxels.
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21. Apparatus for gamma radiation based imaging and analysis of a three dimensional (3D) target area, the apparatus comprising:
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an imaging circuit configured to obtain gamma radiation emission data from said 3D target area in spatial dimensions and at least one other dimension in a single imaging session, as one or more images; and an image multi-dimensional analysis circuit associated with said imaging circuit for analyzing said obtained one or more images in said spatial dimensions and said at least one other dimension in order to discern patterns within a respective target region; wherein said at least one other dimension is indicative of radiation data of at least one radiopharmaceutical in said respective target region during a single imaging session. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method of optimization of therapy of the human or animal body, comprising:
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identifying a three dimensional (3D) target region for said therapy; applying to a patient at least one radioactive marker; obtaining gamma radiation emission data from said 3D target region in spatial dimensions and at least one other dimension during a single imaging session, as one or more images; and analyzing said obtained one or more images in spatial dimensions and at least one other dimension in order to discern patterns across said dimensions, thereby to characterize said 3D target region, and optimizing said therapy based on said characterization.
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38. Apparatus for multi-dimensional image reconstruction based on data acquired from an imaging circuit for obtaining gamma radiation intensity data from a three dimensional (3D) target region in spatial dimensions and at least one other dimension, the apparatus comprising:
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an image four-dimension analysis circuit configured to analyze said obtained intensity data in said spatial dimension and said at least one other dimension during a single imaging session, as one or more images, in order to map at least one distinguishable region in terms of a property, said property being that of at least one member of the group consisting of a tissue, a disease, a disease stage and a physiological process; wherein said at least one other dimension is indicative of radiation data of at least one radiopharmaceutical in said target area during said single imaging session. - View Dependent Claims (39, 40)
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Specification