Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
First Claim
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1. An apparatus for selective denervation of a target tissue in a patient'"'"'s body, the target tissue comprising nerve cells, the apparatus comprising:
- a non-implantable intraluminal catheter adapted to be percutaneously introduced into a lumen of an artery, the catheter having one or more electrodes disposed thereon, wherein said electrode(s) are adapted to transmit at least one of an electrical pulse or a series of electrical pulses; and
a pulse generator operatively connected to the catheter, wherein the electrodes and generator are configured to deliver cellular poration energy in the range from 10 V/cm to 106 V/cm to nerve cells outside the lumen of the artery to disrupt a pain conduction pathway by inducing apoptosis of the nerve cells, wherein the pulse generator is electrically connected to a proximal end of the intraluminal catheter outside the patient'"'"'s body to deliver cellular poration energy to the one or more electrodes when the catheter is percutaneously introduced into the lumen of the artery.
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Abstract
Methods and apparatus are provided for selective destruction or temporary disruption of nerves and/or conduction pathways in a mammalian body for the treatment of pain and other disorders. Apparatus comprises catheters having electrodes for targeting and affecting nerve tissue at a cellular level to reversible and irreversible nerve poration and incapacitation.
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Citations
20 Claims
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1. An apparatus for selective denervation of a target tissue in a patient'"'"'s body, the target tissue comprising nerve cells, the apparatus comprising:
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a non-implantable intraluminal catheter adapted to be percutaneously introduced into a lumen of an artery, the catheter having one or more electrodes disposed thereon, wherein said electrode(s) are adapted to transmit at least one of an electrical pulse or a series of electrical pulses; and a pulse generator operatively connected to the catheter, wherein the electrodes and generator are configured to deliver cellular poration energy in the range from 10 V/cm to 106 V/cm to nerve cells outside the lumen of the artery to disrupt a pain conduction pathway by inducing apoptosis of the nerve cells, wherein the pulse generator is electrically connected to a proximal end of the intraluminal catheter outside the patient'"'"'s body to deliver cellular poration energy to the one or more electrodes when the catheter is percutaneously introduced into the lumen of the artery. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus for selective denervation of a target tissue, the target tissue comprising nerve cells having membranes, the apparatus comprising:
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an electrode support having one or more electrodes disposed thereon, wherein said electrode(s) are adapted to transmit at least one of an electrical pulse or a series of electrical pulses; and a pulse generator operatively connected to the electrode support, wherein the electrodes and generator are configured to deliver cellular poration energy in the range from 10 V/cm to 106 V/cm for durations from 10 μ
sec to 100 msec to disrupt a pain conduction pathway by disrupting target-tissue nerve-cell membranes,wherein the support comprises a patch and the one or more electrodes are configured on the patch to be applied to a skin. - View Dependent Claims (7)
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- 8. A method for selective denervation of a targeted tissue of a patient, said method comprising delivering energy to target nerve cells of said target tissue under conditions selected to disrupt a pain conduction pathway-by permeabilizing a cell membrane of said target nerve cells.
Specification