Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
First Claim
1. A method of treating cancer, comprising:
- administering to a human in need thereof a monoclonal anti-LOXL2 antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof specifically binds to SEQ ID NO;
3, 7, 11, or 16.
2 Assignments
0 Petitions
Accused Products
Abstract
The present disclosure provides methodology and compositions for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX or LOXL, or a synergistic combination thereof combined with other therapeutic agents. Methods and compositions for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL.
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Citations
44 Claims
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1. A method of treating cancer, comprising:
administering to a human in need thereof a monoclonal anti-LOXL2 antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof specifically binds to SEQ ID NO;
3, 7, 11, or 16.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of treating cancer, comprising:
administering to a human in need thereof a monoclonal anti-LOXL2 antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof specifically binds to a peptide consisting of SEQ ID NO;
3, SEQ ID NO;
7, SEQ ID NO;
11, or SEQ ID NO;
16.- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of treating cancer, comprising:
administering to a human in need thereof a monoclonal anti-LOXL2 antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof specifically binds to SEQ ID NO;
5.- View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
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36. A method of treating cancer, comprising:
administering to a human in need thereof a monoclonal anti-LOXL2 antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof specifically binds to a peptide consisting of SEQ ID NO;
5.- View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44)
Specification