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Immunoglobulin Fc polypeptides

  • US 8,679,493 B2
  • Filed: 06/30/2010
  • Issued: 03/25/2014
  • Est. Priority Date: 06/30/2009
  • Status: Active Grant
First Claim
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1. A polypeptide comprising an aglycosylated antibody Fc domain capable of binding a human FcR polypeptide, wherein the Fc domain comprises an amino acid substitution at amino acids 382 and 428 and at least one additional substitution at any of the following amino acids:

  • 241, 251, 266, 269, 276, 279, 286, 295, 297, 300, 315, 325, 328, 330, 332, 338, 340, 341, 348, 369, 378, 392, 424 and/or 434, where said amino acids are designated according to the Kabat numbering system.

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