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Oncolytic viruses and methods for treating neoplastic disorders

  • US 8,679,509 B2
  • Filed: 07/09/2010
  • Issued: 03/25/2014
  • Est. Priority Date: 07/10/2009
  • Status: Active Grant
First Claim
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1. An Orthopoxvirus comprising a gene encoding a modified R2 protein comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:

  • 1,wherein the modified R2 protein expressed by the Orthopoxvirus comprises a substitution of a tyrosine residue, wherein the substituted tyrosine residue corresponds to position 300 of SEQ ID NO;

    1, orwherein the modified R2 protein expressed by the Orthopoxvirus comprises a deletion of all or part of R1 binding domain (R1 BD); and

    wherein the Orthopoxvirus does not express a wild type R2 protein.

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