Polymer membranes for continuous analyte sensors
First Claim
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1. A device for continuous measurement of an analyte concentration, the device comprising:
- an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host; and
a membrane located over the sensor;
wherein the device is configured to provide, at analyte concentrations of from 40 mg/dL to 80 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of no more than 10% over a sensor session of at least 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
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Citations
48 Claims
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1. A device for continuous measurement of an analyte concentration, the device comprising:
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an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host; and a membrane located over the sensor; wherein the device is configured to provide, at analyte concentrations of from 40 mg/dL to 80 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of no more than 10% over a sensor session of at least 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for continuous measurement of an analyte concentration, the system comprising:
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an implantable sensor comprising a sensing region configured to continuously produce in vivo sensor data associated with an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region; a processor configured to process continuous sensor data; and a user interface configured to display information associated with continuous sensor data; wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL and 400 mg/dL, a level of accuracy of a mean absolute relative difference of no more than 10% over a sensor session of at least 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A device for continuous measurement of an analyte concentration, the device comprising:
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an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host; and a membrane located over the sensor; wherein, over a sensor session of at least 3 days, the device is configured to; provide a level of accuracy corresponding to a first mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 80 mg/dL, wherein one or more reference measurements associated with calculation of the first mean absolute relative difference are determined by analysis of blood; and provide a level of accuracy corresponding to a second mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 400 mg/dL, wherein one or more reference measurements associated with calculation of the second mean absolute relative difference are determined by analysis of blood; and wherein the first mean absolute relative difference value is less than or equal to the second mean absolute relative difference value. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A system for continuous measurement of an analyte concentration, the system comprising:
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an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensor; a processor configured to process continuous sensor data; and a user interface configured to display information associated with continuous sensor data; wherein, over a sensor session of at least 3 days, the system is configured to; provide a level of accuracy corresponding to a first mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 80 mg/dL, wherein one or more reference measurements associated with calculation of the first mean absolute relative difference are determined by analysis of blood; and provide a level of accuracy corresponding to a second mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 400 mg/dL, wherein one or more reference measurements associated with calculation of the second mean absolute relative difference are determined by analysis of blood; and wherein the first mean absolute relative difference value is less than or equal to the second mean absolute relative difference value. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification