Patient management system for treating depression using an implantable medical device

• US 8,682,445 B2
• Filed: 07/28/2006
• Issued: 03/25/2014
• Est. Priority Date: 07/28/2006
• Status: Active Grant

• Current Assignee: LivaNova USA, Inc. (LivaNova Plc)
• Original Assignee: Cyberonics, Inc
• Inventors: Patel, Sejal B., Begnaud, Jason D., DuPont, Chris G., Rodriguez, Albert A.
• Primary Examiner(s): Porter, Jr., Allen
• Application Number:
  US11/495,471
• Publication Number:
  US 20080027487A1
• Time in Patent Office: 2,797 Days
• Field of Search: 607/45, 607/59, 607/30, 600/300
• US Class Current: 607/60
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

A method, system, graphical user interface, and apparatus are provided for performing a patient management function for treating depression using an implantable medical device. At least one patient parameter relating to an electrical signal provided by the implantable medical device for treating depression is acquired. At least one therapy parameter defining the electrical signal is correlated with at least one patient parameter. An indication relating to the correlation of the therapy parameter and the patient parameter is provided.

Claims

1. A method comprising:

acquiring, at a patient management unit, therapy parameter data relating to an electrical signal provided by an implantable medical device to a cranial nerve of a particular patient;

generating, at the patient management unit, data representing a depression therapy regimen provided to the particular patient, wherein the data further represents a relationship between the therapy parameter data and second therapy parameter data associated with one or more other patients, wherein the particular patient is distinct from the one or more other patients;

displaying, at a display device of the patient management unit, a graphical representation that depicts the data representing the depression therapy regimen;

displaying, at the display device, adjustment information indicating one or more suggested adjustments to one or more parameters of the electrical signal for providing the depression therapy regimen, wherein the one or more suggested adjustments are determined based on a depression score and a quality of life parameter; and

modifying, at the patient management unit, the depression therapy regimen based at least in part on the relationship between the therapy parameter data and the second therapy parameter data.

2. The method of claim 1, further comprising:

receiving, at the patient management unit, at least a portion of physician evaluation data from a healthcare provider; and

determining, at the patient management unit, a second relationship between the therapy parameter data and the portion of the physician evaluation data.

3. The method of claim 2, wherein the physician evaluation data is based at least in part on an evaluation from the healthcare provider associated with the particular patient, and wherein the evaluation is based on a patient alertness parameter, a patient verbal skills parameter, a patient mood parameter, a patient achievement parameter, a patient memory parameter, an energy level parameter, a performance parameter, a concentration level parameter, an emotional parameter, a mental overview parameter, a coordination parameter, a balance parameter, an amount of sleep parameter, a sexual function level parameter, or a combination thereof.

4. The method of claim 2,

wherein the graphical representation further depicts one or more first trends related to a magnitude of the physician evaluation data and one or more second trends related to a magnitude of at least one of a plurality of user selected therapy parameters;

wherein the plurality of user selected therapy parameters comprises at least one of a plurality of electrical signal parameters, at least one of a plurality of medication parameters, or both;

wherein the plurality of electrical signal parameters comprises a current amplitude, a voltage amplitude, a rate of change of the current amplitude, a time period of the rate of change of the current amplitude, a rate of change of the voltage amplitude, a time period of the rate of change of the voltage amplitude, a pulse width, a rate of change of the pulse width, a time period of the rate of change of the pulse width, a frequency, a rate of change of the frequency, a time period of the rate of change of the frequency, a signal on time, a signal off time, or a combination thereof; and

wherein the plurality of medication parameters comprises a name of a medication, a dosage of the medication, or a combination thereof.

5. The method of claim 2, further comprising providing an interface that enables modification of the graphical representation to further depict data corresponding to one or more parameters of the therapy parameter data, one or more parameters of the physician evaluation data, or both.

6. The method of claim 5, wherein the interface comprises a graphical user interface for receiving a value of at least one therapy parameter, wherein the at least one therapy parameter is associated with a medication, a dosage associated with the medication, or both.

7. The method of claim 2, wherein the graphical representation further depicts:

values of the physician evaluation data corresponding to a plurality of time intervals; and

values of the therapy parameter data corresponding to the plurality of time intervals.

8. The method of claim 2, wherein the physician evaluation data is related to a condition of the particular patient and wherein the physician evaluation data comprises a side effect parameter including a breathing rate, a heart rate, or both.

9. The method of claim 8, wherein the side effect parameter is sensed by the implantable medical device.

10. The method of claim 1, wherein the graphical representation further depicts sensed body parameter data, wherein the sensed body parameter data comprises a value sensed by the implantable medical device from a tissue of the particular patient, and wherein the depression therapy regimen is further modified based at least in part on the sensed body parameter data.

11. The method of claim 10, wherein the implantable medical device uses the sensed body parameter as feedback to modify the electrical signal provided to the cranial nerve of the particular patient within stimulation parameters that correspond to the depression therapy regimen.

12. The method of claim 1, wherein the therapy parameter data comprises an indication of a current amplitude, a voltage amplitude, a rate of change of the current amplitude, a time period of the rate of change of the current amplitude, a rate of change of the voltage amplitude, a time period of the rate of change of the voltage amplitude, a pulse width, a rate of change of the pulse width, a time period of the rate of change of the pulse width, a frequency, a rate of change of the frequency, a time period of the rate of change of the frequency, a signal on time, a signal off time, or a combination thereof.

13. The method of claim 1, wherein the implantable medical device provides passive stimulation to the cranial nerve of the particular patient within stimulation parameters that correspond to the depression therapy regimen.

14. The method of claim 1, wherein the graphical representation further depicts one or more trends, wherein the one or more trends comprise one or more scores over a plurality of time intervals, and wherein each of the one or more scores comprise a value sensed by the implantable medical device.

15. The method of claim 14, wherein the one or more scores comprise the depression score.

16. The method of claim 14, wherein the one or more scores comprise the quality of life parameter.

17. The method of claim 14, further comprising receiving a selection of the one or more trends and the one or more scores to be depicted by the graphical representation.

18. A computer readable program storage device encoded with instructions that, when executed by a processor, cause the processor to:

acquire, at a patient management unit, therapy parameter data relating to an electrical signal provided by an implantable medical device to a cranial nerve of a particular patient;

generate, at the patient management unit, data representing a depression therapy regimen provided to the particular patient, wherein the data further represents a relationship between the therapy parameter data and second therapy parameter data associated with one or more other patients, wherein the particular patient is distinct from the one or more other patients;

display, at a display device of the patient management unit, a graphical representation that depicts the data representing the depression therapy regimen;

display, at the display device, adjustment information indicating one or more suggested adjustments to one or more parameters of the electrical signal for providing the depression therapy regimen, wherein the one or more suggested adjustments are determined based on a depression score and a quality of life parameter; and

modify, at the patient management unit, the depression therapy regimen based at least in part on the relationship between the therapy parameter data and the second therapy parameter data.

19. The computer readable program storage device of claim 18, wherein the instructions are further executable by the processor to receive, at the patient management unit, at least a portion of physician evaluation data from a healthcare provider.

20. The computer readable program storage device of claim 19, wherein the graphical representation further depicts a second relationship of historical values of a first parameter of the physician evaluation data, a third relationship of historical values of a second parameter of the physician evaluation data, and a trend of historical values corresponding to the therapy parameter data.

21. The computer readable program storage device of claim 20, wherein the instructions are further executable by the processor to receive input associated with a third parameter of the physician evaluation data, wherein the third parameter is distinct from the first parameter and is distinct from the second parameter, wherein the graphical representation is modified responsive to the input to display a fourth relationship between historical values of the third parameter of the physician evaluation data and the historical values corresponding to the therapy parameter data.