Device including altered microorganisms, and methods and systems of use
First Claim
Patent Images
1. A system comprising:
- at least one computing device;
at least one implantable treatment device including at least one bone cage permeable to only material less than or equal to 1 micrometer, the at least one bone cage substantially enclosing at least one auxotrophic prokaryote or eukaryote, the at least one auxotrophic prokaryote or eukaryote including at least one nucleic acid construct encoding at least one therapeutic agent, the at least one bone cage defining an interior region and exterior region;
wherein the device includes at least one metabolite required by the at least one auxotrophic prokaryote or eukaryote;
the implantable treatment device further comprising at least one pump for dispensing the at least one therapeutic agent, the pump including electronic circuitry configured to send or receive signals from the computing device; and
one or more instructions on a recordable medium that when executed on the computing device cause the computing device to regulate dispensing of the at least one therapeutic agent from the at least one implantable treatment device.
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Abstract
Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
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Citations
55 Claims
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1. A system comprising:
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at least one computing device; at least one implantable treatment device including at least one bone cage permeable to only material less than or equal to 1 micrometer, the at least one bone cage substantially enclosing at least one auxotrophic prokaryote or eukaryote, the at least one auxotrophic prokaryote or eukaryote including at least one nucleic acid construct encoding at least one therapeutic agent, the at least one bone cage defining an interior region and exterior region;
wherein the device includes at least one metabolite required by the at least one auxotrophic prokaryote or eukaryote;the implantable treatment device further comprising at least one pump for dispensing the at least one therapeutic agent, the pump including electronic circuitry configured to send or receive signals from the computing device; and one or more instructions on a recordable medium that when executed on the computing device cause the computing device to regulate dispensing of the at least one therapeutic agent from the at least one implantable treatment device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A system comprising:
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at least one computing device; one or more instructions on a recordable medium that when executed on the at least one computing device cause the at least one computing device to receive a first input associated with a first possible dataset; the first possible dataset including data representative of at least one parameter for making or administering at least one implantable treatment device to at least one biological tissue, wherein the at least one implantable treatment device including at least one bone cage permeable to only material less than or equal to 1 micrometer, the at least one bone cage structured to substantially enclose at least one auxotrophic prokaryote or eukaryote; wherein the at least one auxotrophic prokaryote or eukaryote includes at least one nucleic acid construct encoding at least one therapeutic agent; and one or more instructions on a recordable medium that when executed on the at least one computing device cause the computing device to generate an output to a user readable display. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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55. A system comprising:
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at least one computing device; at least one implantable treatment device including at least one bone cage permeable to only material less than or equal to 1 micrometer, the at least one bone cage substantially enclosing at least one auxotrophic prokaryote or eukaryote, the at least one auxotrophic prokaryote or eukaryote including at least one nucleic acid construct encoding at least one cytokine, the at least one bone cage defining an interior region and exterior region;
wherein the device includes at least one metabolite required by the at least one auxotrophic prokaryote or eukaryote;the implantable treatment device further comprising at least one pump for dispensing the at least one cytokine, the pump including electronic circuitry configured to send or receive signals from the computing device; and one or more instructions on a recordable medium that when executed on the computing device cause the computing device to regulate dispensing of the at least one therapeutic agent from the at least one implantable treatment device.
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Specification