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Device including altered microorganisms, and methods and systems of use

  • US 8,682,619 B2
  • Filed: 05/28/2010
  • Issued: 03/25/2014
  • Est. Priority Date: 12/14/2005
  • Status: Expired due to Fees
First Claim
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1. A system comprising:

  • at least one computing device;

    at least one implantable treatment device including at least one bone cage permeable to only material less than or equal to 1 micrometer, the at least one bone cage substantially enclosing at least one auxotrophic prokaryote or eukaryote, the at least one auxotrophic prokaryote or eukaryote including at least one nucleic acid construct encoding at least one therapeutic agent, the at least one bone cage defining an interior region and exterior region;

    wherein the device includes at least one metabolite required by the at least one auxotrophic prokaryote or eukaryote;

    the implantable treatment device further comprising at least one pump for dispensing the at least one therapeutic agent, the pump including electronic circuitry configured to send or receive signals from the computing device; and

    one or more instructions on a recordable medium that when executed on the computing device cause the computing device to regulate dispensing of the at least one therapeutic agent from the at least one implantable treatment device.

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