Methods and systems for presenting a combination treatment

• US 8,682,687 B2
• Filed: 11/26/2008
• Issued: 03/25/2014
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Harvest Bio LLC
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Sweeney, Elizabeth A., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): NGUYEN, HIEP VAN
• Application Number:
  US12/315,072
• Publication Number:
  US 20090270786A1
• Time in Patent Office: 1,945 Days
• Field of Search: 705/2
• US Class Current: 705/2
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/20 for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms

Abstract

Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of a bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the bioactive agent to the individual.

Claims

1. A computer-implemented method, comprising:

accepting a pharmacokinetic profile of a prescribed bioactive agent;

accepting, using a suitable microprocessor, an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual; and

presenting a prescription for engagement of the individual with a virtual experience at at least one time when a concentration of the prescribed bioactive agent is expected to be below a substantially effective level at least partly based on accepting the pharmacokinetic profile of the prescribed bioactive agent and at least partially based on accepting the indication of the prescribed schedule for administration of the prescribed bioactive agent to the individual, the pharmacokinetic profile of the prescribed bioactive agent including at least one or more effective concentration levels of the prescribed bioactive agent.

2. A system, comprising:

means for accepting a pharmacokinetic profile of a prescribed bioactive agent;

means for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual; and

means for presenting a prescription for engagement of the individual with a virtual experience at at least one time when a concentration of the prescribed bioactive agent is expected to be below a substantially effective level at least partly based on accepting the pharmacokinetic profile of the prescribed bioactive agent and at least partially based on accepting the indication of the prescribed schedule for administration of the prescribed bioactive agent to the individual, the pharmacokinetic profile of the prescribed bioactive agent including at least one or more effective concentration levels of the prescribed bioactive agent.

3. The system of claim 2, wherein the means for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual comprises:

means for accepting a bioactive agent time schedule.

4. The system of claim 2, wherein the means for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual comprises:

means for accepting at least one of a bioactive agent delivery type or bioactive agent delivery dosage administration schedule.

5. The system of claim 2, wherein the means for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual comprises:

means for accepting a bioactive agent loading dose.

6. The system of claim 2, further comprising:

means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent.

7. The system of claim 6, wherein the means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent comprises:

means for accepting an indication of a time versus concentration representation for a bioactive agent.

8. The system of claim 6, wherein the means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent comprises:

means for accepting an indication of a dose versus response representation for a bioactive agent.

9. The system of claim 6, wherein the means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent comprises:

means for accepting a pharmacokinetic model.

10. The system of claim 9, wherein the means for accepting a pharmacokinetic model comprises:

means for accepting a physiologically-based pharmacokinetic model.

11. The system of claim 9, wherein the means for accepting a pharmacokinetic model comprises:

means for accepting an output from physiologically-based pharmacokinetic modeling software.

12. The system of claim 6, wherein the means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent comprises:

means for accepting pharmacokinetic profile information for a bioactive agent including at least one of an absorption characteristic, a distribution characteristic, a metabolization characteristic, or an excretion characteristic.

13. The system of claim 6, wherein the means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent comprises:

means for accepting an indication of a pharmacokinetic profile at least partly based on at least one attribute of the individual.

14. The system of claim 6, wherein the means for accepting an indication of at least one of a pharmacokinetic or pharmacodynamic profile of a bioactive agent comprises:

means for accepting at least one of a Tmin, Tmax, Cmin, or a Cmax value for the bioactive agent.

15. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for presenting an indication of a prescribed virtual experience.

16. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for utilizing an algorithm for recommending at least one virtual experience.

17. The system of claim 16, wherein the means for utilizing an algorithm for recommending at least one virtual experience comprises:

means for utilizing pharmacokinetic modeling software.

18. The system of claim 16, wherein the means for utilizing an algorithm for recommending at least one virtual experience comprises:

means for utilizing pharmacodynamic modeling software.

19. The system of claim 16, wherein the means for utilizing an algorithm for recommending at least one virtual experience comprises:

means for utilizing an algorithm configured for identifying a contraindication of the virtual experience.

20. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for presenting the prescription for engagement of the individual with the virtual experience at least partly based on a personal medical history.

21. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for presenting the prescription of the individual with the virtual experience at least partly based on experimental data.

22. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for presenting the prescription for engagement of the individual with the virtual experience at least partly based on a medical reference tool.

23. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for presenting the prescription for engagement of the individual with the virtual experience to at least one output device.

24. The system of claim 2, wherein the means for presenting a prescription for engagement of the individual with a virtual experience comprises:

means for presenting the prescription for engagement of the individual with the virtual experience to a third party.

25. The system of claim 24, wherein the means for presenting the prescription for engagement of the individual with the virtual experience to a third party comprises:

means for presenting the prescription for engagement of the individual with the virtual experience to a health care provider.

26. The system of claim 24, wherein the means for presenting the prescription for engagement of the individual with the virtual experience to a third party comprises:

means for selectively presenting the prescription for engagement of the individual with the virtual experience only to the individual.

27. The system of claim 2, wherein the means for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual and means for presenting a prescription for engagement of the individual with a virtual experience at at least one time when a concentration of the prescribed bioactive agent is expected to be below a substantially effective level at least partly based on accepting the pharmacokinetic profile of the prescribed bioactive agent and at least partially based on accepting the indication of the prescribed schedule for administration of the prescribed bioactive agent to the individual comprises:

means for accepting the pharmacokinetic profile of immediate release oxycodone, means for accepting a prescribed administration schedule of the immediate release oxycodone to an individual, and means for presenting a prescription for engagement of the individual with a virtual experience at times when the plasma concentration of the immediate release oxycodone is expected to be below a substantially effective level based on the pharmacokinetic profile of the immediate release oxycodone and the prescribed administration schedule of the immediate release oxycodone.

28. A system, comprising:

circuitry for accepting a pharmacokinetic profile of a prescribed bioactive agent;

circuitry for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual; and

circuitry for presenting a prescription for engagement of the individual with a virtual experience at at least one time when a concentration of the prescribed bioactive agent is expected to be below a substantially effective level at least partly based on accepting the pharmacokinetic profile of the prescribed bioactive agent and at least partially based on accepting the indication of the prescribed schedule for administration of the prescribed bioactive agent to the individual, the pharmacokinetic profile of the prescribed bioactive agent including at least one or more effective concentration levels of the prescribed bioactive agent.

29. A computer program product comprising:

a non-transitory signal-bearing medium bearing one or more instructions for accepting a pharmacokinetic profile of a prescribed bioactive agent;

one or more instructions for accepting an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual; and

one or more instructions for presenting a prescription for engagement of the individual with a virtual experience at at least one time when a concentration of the prescribed bioactive agent is expected to be below a substantially effective level at least partly based on accepting the pharmacokinetic profile of the prescribed bioactive agent and at least partially based on accepting the indication of the prescribed schedule for administration of the prescribed bioactive agent to the individual, the pharmacokinetic profile of the prescribed bioactive agent including at least one or more effective concentration levels of the prescribed bioactive agent.

30. The computer program product of claim 29, wherein the signal-bearing medium includes a computer-readable medium.

31. The computer program product of claim 29, wherein the signal-bearing medium includes a recordable medium.

32. The computer program product of claim 29, wherein the signal-bearing medium includes a communications medium.

33. A system comprising:

a computing device; and

one or more instructions that when executed on the computing device cause the computing device to at least;

accept a pharmacokinetic profile of a prescribed bioactive agent;

accept an indication of a prescribed schedule for administration of the prescribed bioactive agent to an individual; and

present a prescription for engagement of the individual with a virtual experience at at least one time when a concentration of the prescribed bioactive agent is expected to be below a substantially effective level at least partly based on accepting the pharmacokinetic profile of the prescribed bioactive agent and at least partially based on accepting the indication of the prescribed schedule for administration of the prescribed bioactive agent to the individual, the pharmacokinetic profile of the prescribed bioactive agent including at least one or more effective concentration levels of the prescribed bioactive agent.

34. The system of claim 33 wherein the computing device comprises:

one or more of a personal digital assistant (PDA), a personal entertainment device, a mobile phone, a laptop computer, a tablet personal computer, a networked computer, a computing system comprised of a cluster of processors, a computing system comprised of a cluster of servers, a workstation computer, and/or a desktop computer.

35. The system of claim 33, wherein the computing device is operable to accept the at least one attribute of the at least one individual and present the indication of the at least one prescription medication and the at least one virtual experience from at least one memory.