Blood pump with expandable cannula

• US 8,684,904 B2
• Filed: 08/15/2013
• Issued: 04/01/2014
• Est. Priority Date: 07/01/2009
• Status: Active Grant

• Current Assignee: Penn State Research Foundation, Thoratec LLC
• Original Assignee: Penn State Research Foundation, Thoratec LLC
• Inventors: Campbell, Robert L., Walsh, Justin M., Metrey, Daniel, Kunz, Robert F., Mallison, Thomas M., Boone, Edward, Myer, Eric, McBride, Mark W., Powell, Kevin J., Walters, Daniel A.
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US13/968,161
• Publication Number:
  US 20130331639A1
• Time in Patent Office: 229 Days
• Field of Search: 600/16, 607/46, 607 59- 60
• US Class Current: 600/16
• CPC Class Codes: A61M 60/13 by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
• CPC Class Codes: A61M 60/139 inside the aorta, e.g. intra-aortic balloon pumps
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/237 the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
• CPC Class Codes: A61M 60/414 transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
• CPC Class Codes: A61M 60/422 the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
• CPC Class Codes: A61M 60/808 specially adapted for deformable impellers, e.g. expandable impellers
• CPC Class Codes: A61M 60/857 Implantable blood tubes
• CPC Class Codes: A61M 60/894 Passive valves, i.e. valves actuated by the blood

Abstract

A blood pump includes an impeller having a plurality of foldable blades and a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller can reside in the expandable portion of the cannula. The cannula has a collapsed condition for percutaneous delivery to a desired location within the body, and an expanded condition in which the impeller can rotate to pump blood. A flexible drive shaft can extend through the cannula for rotationally driving the impeller within the patient'"'"'s body.

Claims

1. A pump, comprising:

an elongated cannula having a proximal portion and a distal portion;

an impeller positioned in the elongated cannula and configured to rotate about an axis; and

an expandable vane assembly positioned in the elongated cannula about the axis adjacent the impeller and having a deployed configuration and a stored configuration, the vane assembly comprising a vane, the vane in the deployed configuration extending away from the axis, the vane in the stored configuration compressed inwardly towards the axis relative to the deployed configuration.

2. The pump of claim 1, wherein the vane is configured to expand to the deployed configuration by release of strain stored in the vane.

3. The pump of claim 1, wherein the distal portion of the elongated cannula includes an expandable portion having an expanded configuration and a collapsed configuration, the vane assembly disposed in the expandable portion.

4. The pump of claim 3, wherein the vane assembly is configured to move from the stored configuration to the deployed configuration when the expandable portion moves from the collapsed configuration to the expanded configuration.

5. The pump of claim 3, wherein a free end of the vane contacts an inner wall of the expandable portion when the vane assembly is in the deployed configuration.

6. The pump of claim 5, wherein the vane assembly is positioned distally of the impeller.

7. The pump of claim 6, wherein the vane assembly is configured to maintain the impeller substantially centered in the expandable portion of the cannula during operation of the pump.

8. The pump of claim 6, wherein the impeller comprises a blade, and wherein the vane assembly is configured to maintain a consistent clearance between a tip of the blade and the inner wall of the expandable portion of the elongated cannula during operation of the pump.

9. The pump of claim 1, wherein the vane assembly comprises:

a vane hub; and

a plurality of vanes supported by the vane hub, each of the vanes having a proximal end attached to the vane hub and a distal end,

the vanes in the deployed configuration of the vane assembly extending away from the vane hub, and the vanes in the stored configuration of the vane assembly being compressed so as to move the distal ends of the vanes towards the vane hub.

10. The pump of claim 1, wherein the vane is oriented at an angle to a direction of blood flow through the elongated cannula.

11. The pump of claim 10, wherein the vane is angled to induce a circumferential velocity component to the blood flow.

12. The pump of claim 1, wherein the vane assembly is mechanically coupled to the impeller along the axis but does not rotate with the impeller.

13. The pump of claim 12, wherein the impeller comprises a hub and a blade, the vane assembly mounted to a distal end of the impeller.

14. The pump of claim 13, further comprising:

a lumen extending axially through the hub of the impeller and the vane assembly, the lumen adapted to receive a guidewire therethrough for guiding the impeller and vane assembly to a target site in the anatomy of a patient; and

a seal positioned within the lumen, the seal configured to prevent a flow of fluid into the lumen after the guidewire is removed.

15. The pump of claim 14, wherein the seal is disposed in a portion of the lumen that is within the vane assembly.

16. The pump of claim 3, further comprising a retainer sheath disposed over a portion of the elongated cannula, the retainer sheath configured to cause the expandable portion to move from the collapsed configuration to the expanded configuration by moving the retainer sheath proximally relative to the expandable portion such that the expandable portion self-expands to the expanded configuration, and

wherein the retainer sheath is configured to cause the expandable portion to move from the expanded configuration to the collapsed configuration by moving the retainer sheath distally over the expandable portion to collapse the expandable portion to the collapsed configuration.

17. A pump, comprising:

an elongated cannula having a proximal portion and a distal portion, the distal portion comprising an expandable portion;

an impeller disposed in the expandable portion;

a sheath having a generally non-expanding distal portion; and

one or more guidance aids configured to facilitate retraction of the expandable portion into the distal portion of the sheath when relative motion is provided between the distal portion of the sheath and the expandable portion.

18. The pump of claim 17, wherein the one or more guidance aids is configured such that relative axial motion between the distal portion of the sheath and the expandable portion applies a force having a radial component to a proximal end of the one or more guidance aids to induce radial collapse of the expandable portion into the sheath.

19. The pump of claim 17, wherein the expandable portion comprises a plurality of undulating circumferential rings and the guidance aid comprises an axial member coupled at a distal end with a portion of one of the circumferential rings and a proximal end disposed proximally of the distal end.

20. The pump of claim 19, wherein the proximal end of the axial member is coupled with an apex of a proximal circumferential ring and the distal end of the axial member is coupled with an apex of a distal circumferential ring.

21. The pump of claim 19, wherein the axial member connects an apex of one circumferential ring to a side of an adjacent circumferential ring.

22. The pump of claim 17, wherein the one or more guidance aids comprises a polymeric rib structure disposed axially along the expandable portion.

23. A method of pumping blood in a patient, comprising:

inserting a blood pump into the patient, the blood pump comprising an elongated cannula, an impeller positioned in the elongated cannula, and an expandable vane assembly positioned in the elongated cannula near the impeller, the expandable vane assembly having a deployed configuration and a stored configuration, the vane assembly comprising a vane;

positioning the blood pump in the patient so that the impeller is at a desired location;

expanding the expandable vane assembly from the stored configuration to the deployed configuration within the elongated cannula; and

rotating the impeller about an axis to pump blood through the elongated cannula.

24. The method of claim 23, wherein the impeller is an expandable impeller having a deployed configuration and a stored configuration, wherein a distal portion of the elongated cannula includes an expandable portion having an expanded configuration and a collapsed configuration, the vane assembly disposed in the expandable portion, the method further comprising:

expanding the expandable impeller from the stored configuration to the deployed configuration; and

expanding the expandable portion from the collapsed configuration to the expanded configuration.

25. The method of claim 24, further comprising:

collapsing the expandable vane assembly from the deployed configuration to the stored configuration such that the vane is compressed inwardly towards the axis relative to the deployed configuration;

collapsing the expandable impeller from the deployed configuration to the stored configuration; and

collapsing the expandable portion of the elongated cannula from the expanded configuration to the stored configuration.

26. The method of claim 25, wherein the blood pump comprises a retainer sheath disposed about the elongated cannula, the method further comprising:

retracting the retainer sheath proximally relative to the expandable portion of the elongated cannula to urge the expandable portion out of the retainer sheath to expand the expandable portion, the expandable impeller, and the expandable vane assembly; and

advancing the retainer sheath distally over the expandable portion to collapse the expandable portion, the expandable impeller, and the expandable vane assembly.

27. The method of claim 24, wherein the impeller comprises a blade, the method further comprising maintaining a consistent clearance between a tip of the blade and an inner wall of the expandable portion.

28. The method of claim 27, wherein maintaining the consistent clearance comprises contacting a free end of the vane with the inner wall of the expandable portion.

29. The method of claim 24, wherein positioning the blood pump in the patient comprises positioning the expandable portion of the elongated cannula such that at least part of the expandable portion is disposed in the right ventricle of the patient.