Apparatus for evaluating biological condition, method for the same, and computer program product

• US 8,684,938 B2
• Filed: 01/18/2010
• Issued: 04/01/2014
• Est. Priority Date: 01/19/2009
• Status: Active Grant

• Current Assignee: DENSO Corporation, Nippon Medical School Foundation, Toyota Jidosha Kabushiki Kaisha (Toyota Motor Corporation)
• Original Assignee: DENSO Corporation, Nippon Medical School Foundation, Toyota Jidosha Kabushiki Kaisha (Toyota Motor Corporation)
• Inventors: Sakai, Kazuhiro, Nanba, Shinji, Katoh, Takao, Fuwamoto, Yoshitaka, Osaka, Motohisa
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): WEARE, MEREDITH H
• Application Number:
  US12/688,994
• Publication Number:
  US 20100185101A1
• Time in Patent Office: 1,534 Days
• Field of Search: 600481-526
• US Class Current: 600/483
• CPC Class Codes: A61B 5/02455 provided with high/low alarm devices
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

A biological condition evaluation apparatus determines a symptom of a heart abnormality based on at least one index calculated from a heartbeat interval and/or a pulse interval. The apparatus determines whether it is in a referential period where an amount of change in the index is comparatively small. The apparatus determines whether a plurality of conditions are satisfied or not in an evaluation period set after the referential period. One condition is that an amount of change in the index in the evaluation period is greater than that observed during the referential period. Another condition is that a rate of change in the index is equal to or greater than a predetermined threshold value. The apparatus determines that there is a symptom of a heart abnormality, when both the conditions are satisfied.

Claims

1. An apparatus for evaluating biological condition, which determines a symptom of a heart abnormality based on biological information that is at least one of a heartbeat interval and a pulse interval, the apparatus comprising:

means for calculating an index by performing a frequency analysis on at least one of the heartbeat interval and the pulse interval, the index being indicative of the sympathetic nerve activity;

means for determining whether the index is in a referential period, which is a time period in which the index satisfies a predetermined condition which shows that an amount of change in the index calculated in the index calculating means is smaller than a predetermined reference threshold value over a predetermined period; and

means for determining a symptom of a ventricular fibrillation after the predetermined condition for the referential period is satisfied, the symptom being determined when the following both conditions (1) and (2) are satisfied during an evaluation period which is set after the referential period,

(1) both amounts of change in the index in an increasing direction and a decreasing direction are equal to or greater than respective predetermined amount threshold values which indicate that the amount of change is greater than an amount of change in the index observed during the referential period, and

(2) both rates of change in the index in the increasing direction and the decreasing direction are equal to or greater than respective predetermined rate threshold values,

wherein the symptom of the ventricular fibrillation is determined when the index changes rapidly from the decreasing direction to the increasing direction in the evaluation period.

2. The apparatus for evaluating biological condition according to claim 1, wherein

the index is expressed by the natural logarithm.

3. The apparatus for evaluating biological condition according to claim 1, wherein

the predetermined condition for determining the referential period is that the change in the index is equal to or smaller than the predetermined reference threshold value.

4. The apparatus for evaluating biological condition according to claim 1, wherein

the respective predetermined amount threshold value for the amount of change in the index is a value of mean(index)±

1SD, where the mean(index) is an average value of the index in the referential period, and 1SD is a unit of the standard deviation of the index in the referential period.

5. The apparatus for evaluating biological condition according to claim 1, wherein

the respective predetermined amount threshold value for the amount of change in the index is a variable according to the absolute value of the index in the referential period.

6. The apparatus for evaluating biological condition according to claim 1, wherein

the referential period is defined by using past data of the index.

7. The apparatus for evaluating biological condition according to claim 1, wherein

the abnormality determining means determines that the condition (1) for the amount of change in the index is satisfied when the amount of change in the index in the evaluation period is within a range from mean(index)±

1.5SD to mean(index)±

3.0SD, where the mean(index) is an average value of the index in the referential period, and SD is the standard deviation of the index in the referential period.

8. The apparatus for evaluating biological condition according to claim 1, wherein

the abnormality determining means performs the determination based on a gradient of a regression line of the index during the evaluation period.

9. The apparatus for evaluating biological condition according to claim 8, wherein

the determination using the gradient of the regression line is performed by comparing the gradient of the regression line with a predetermined variable gradient threshold value that is variable according to the absolute value of the index during the referential period.

10. The apparatus for evaluating biological condition according to claim 8, wherein

the abnormality determining means changes an abnormal grade showing a grade of the abnormality according to a grade of the gradient of the regression line.

11. The apparatus for evaluating biological condition according to claim 1, wherein

the index calculating means calculates a first index that is the index indicative of the sympathetic nerve activity and a second index indicative of the parasympathetic nerve activity,

the referential period determining means and the abnormality determining means determine the symptom of the heart abnormality based on both of the indexes respectively, and

the abnormality determining means determines a final result of determination when the abnormality determining means determines that both the first and second indexes indicate the symptom of the ventricular fibrillation respectively.

12. The apparatus for evaluating biological condition according to claim 1, wherein

the index calculating means calculates a first index that is the index indicative of the sympathetic nerve activity and a second index indicative of the parasympathetic nerve activity,

the referential period determining means and the abnormality determining means determine the symptom of the ventricular fibrillation based on both of the indexes respectively, and

the abnormality determining means determines an abnormal pattern which is used for the determination by adding a condition in which the first index and the second index change in opposite increasing and decreasing directions.

13. The apparatus for evaluating biological condition according to claim 1, wherein

the abnormality determining means avoids determining the symptom when the abnormality determining means determines that a human which is evaluated for by the apparatus for a biological condition is in a time of beginning sleep, a time of amid sleep, or a time of getting up.

14. The apparatus for evaluating biological condition according to claim 1, wherein

the apparatus is able to be mounted on a vehicle.

15. The apparatus for evaluating biological condition according to claim 1, wherein

the determination is carried out when the vehicle is driven.

16. The apparatus for evaluating biological condition according to claim 1, further comprising:

a sensor which detects biological condition, an output device which outputs an announcement corresponding to the result of the determination, and

a control device which performs control according to the result of the determination, wherein

the sensor performs, in response to the determination of the symptom, at least one measurement among an electrocardiograph measurement, a blood-pressure measurement, and other biological measurement different from one that is used in the determination, and wherein

the output device performs, in response to the determination of the symptom, at least one output among an announcement output suggesting other abnormality determination different from one that is used in the determination, an announcement output asking subjective symptoms, an announcement output suggesting an electrocardiograph measurement, an announcement output suggesting a blood-pressure measurement and an announcement output suggesting other biological measurement different from one that is used in the determination.

17. A method for evaluating biological condition, which determines a symptom of a heart abnormality based on biological information that is at least one of a heartbeat interval and a pulse interval, the method comprising the steps of:

calculating an index with a microcomputer by performing a frequency analysis on at least one of the heartbeat interval and the pulse interval, the index being indicative of the sympathetic nerve activity;

determining, with the microcomputer, whether the index is in a referential period, which is a time period in which the index satisfies a predetermined condition which shows that an amount of change in the index calculated in the index calculating step is smaller than a predetermined reference threshold value over a predetermined period; and

determining, with the microcomputer, a symptom of a ventricular fibrillation after the predetermined condition for the referential period is satisfied, the symptom being determined when the following both conditions (1) and (2) are satisfied during an abnormality evaluation period which is set after the referential period,

(1) both amounts of change in the index in an increasing direction and a decreasing direction are equal to or greater than respective predetermined amount threshold values which indicate that the amount of change is greater than an amount of change in the index observed during the referential period, and

(2) both rates of change in the index in the increasing direction and the decreasing direction are equal to or greater than respective predetermined rate threshold values,

wherein the symptom of the ventricular fibrillation is determined when the index changes rapidly from the decreasing direction to the increasing direction in the evaluation period.

18. The method according to claim 17, wherein

the index calculating step calculates a first index that is the index indicative of the sympathetic nerve activity and a second index indicative of the parasympathetic nerve activity,

the referential period determining step and the symptom determining step determine the symptom of the heart abnormality based on both of the indexes respectively, and

the symptom determining step determines a final result of determination when the symptom determining step determines that both the first and second indexes indicate the symptom of the ventricular fibrillation respectively.

19. The method according to claim 17, wherein the index calculating step calculates a first index that is the index indicative of the sympathetic nerve activity and a second index indicative of the parasympathetic nerve activity,

the referential period determining step and the symptom determining step determine the symptom of the ventricular fibrillation based on both of the indexes respectively, and

the symptom determining step determines an abnormal pattern which is used for the determination by adding a condition in which the first index and the second index change in opposite increasing and decreasing directions.

20. A non-transitory computer-readable medium comprising a computer program that, when executed on a computer, causes the computer to perform the method of claim 17.