Photodynamic bone stabilization and drug delivery systems

• US 8,684,965 B2
• Filed: 04/18/2011
• Issued: 04/01/2014
• Est. Priority Date: 06/21/2010
• Status: Active Grant

• Current Assignee: Illuminoss Medical, Inc.
• Original Assignee: Illuminoss Medical, Inc.
• Inventors: Rabiner, Robert A., Rader, Richard Scott
• Primary Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US13/088,916
• Publication Number:
  US 20110313356A1
• Time in Patent Office: 1,079 Days
• Field of Search: 604/96.01, 604/101.02, 604/103.02, 604/912, 604/917, 604/919, 606/15, 606 92- 93, 623/17.12, 623/17.16
• US Class Current: 604/101.02
• CPC Class Codes: A61B 17/7097 Stabilisers comprising fluid filler in an implant, e.g. balloon; devices for inserting or filling such implants disc prostheses made of inflatable chambers or pockets filled with fluid A61F2/441; replacing the nucleus pulposus A61F2002/444
• CPC Class Codes: A61B 17/7098 wherein the implant is permeable or has openings, e.g. fenestrated screw hollow surgical screws A61B17/864
• CPC Class Codes: A61B 17/7275 with expanding cylindrical parts
• CPC Class Codes: A61B 17/8836 for heating, cooling or curing of bone cement or fluid fillers
• CPC Class Codes: A61B 17/8855 inflatable, e.g. kyphoplasty balloons
• CPC Class Codes: A61B 2017/00411 actuated by application of energy from an energy source outside the body
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1075 having a balloon composed of several layers, e.g. by coating or embedding
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61N 2005/0612 using probes penetrating tissue; interstitial probes
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

Photodynamic bone stabilization and drug delivery systems are disclosed herein. In an embodiment, a photodynamic bone stabilization and drug delivery system of the present disclosure includes an insertion catheter having an inner void for passing at least one light-sensitive liquid, and an inner lumen; an expandable portion releasably engaging a distal end of the insertion catheter, wherein the expandable portion comprises an inner expandable portion in communication with the inner lumen of the insertion catheter and sufficiently designed to maintain a light-sensitive liquid therein; and an outer expandable portion, surrounding the inner expandable portion, sufficiently designed to house and release at least one additive from the outer expandable portion in an outward direction from the inner expandable portion; and a light-conducting fiber sized to pass through the inner lumen of the insertion catheter and into the inner expandable portion for delivering light energy to the light-sensitive liquid.

Claims

1. A photodynamic bone stabilization and drug delivery system for repairing a fractured bone comprising:

an insertion catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, the insertion catheter having an inner void for passing at least one light-sensitive liquid, and an inner lumen;

an expandable portion releasably engaging the distal end of the insertion catheter, wherein the expandable portion comprises;

an inner expandable portion fabricated from a non-permeable material, wherein the inner expandable portion is in communication with the inner lumen of the insertion catheter and wherein the inner expandable portion is sufficiently designed to maintain a light-sensitive liquid within the inner expandable portion; and

an outer expandable portion, surrounding the inner expandable portion, sufficiently designed to house and release at least one additive from the outer expandable portion in an outward direction from the inner expandable portion and into an intramedullary canal of the fractured bone; and

a light-conducting fiber, wherein the light-conducting fiber is sized to pass through the inner lumen of the insertion catheter and into the inner expandable portion for delivering light energy to the light-sensitive liquid to cure the light-sensitive liquid within the inner expandable portion,

wherein at least one of an outer surface of the inner expandable portion or an inner surface of the outer expandable portion includes a textured surface.

2. The system of claim 1, wherein the light-conducting fiber emits light radially in a uniform manner along a length of the light-conducting fiber.

3. The system of claim 1, wherein the outer expandable portion includes one or more porous sections designed to release the at least one additive.

4. The system of claim 3, wherein the one or more porous sections of the outer expandable portion are fabricated from a non-porous polymer material.

5. The system of claim 3, wherein the one or more porous sections of the outer expandable portion are fabricated from a porous polymer material.

6. The system of claim 3, wherein the one or more porous sections of the outer expandable portion extend along a section of the outer expandable portion.

7. The system of claim 3, wherein the one or more porous sections include a plurality of pores having sizes and shapes that are substantially non-uniform throughout the porous section.

8. The system of claim 3, wherein the one or more porous sections include a plurality of pores having sizes and shapes that are substantially uniform throughout the porous section.

9. The system of claim 1, wherein the outer expandable portion is fabricated from a porous polymer.

10. The system of claim 1 further comprising a tube in fluid communication with the outer expandable portion and a port disposed at a distal end of the tube.

11. The system of claim 1, wherein the outer expandable portion and the inner expandable portion are fabricated from a thin-walled noncompliant material.

12. The system of claim 1, further comprising an adapter engaging the proximal end of the insertion catheter.

13. The system of claim 1, further comprising a syringe housing a light-sensitive liquid, the syringe engaging the proximal end of the insertion catheter.

14. The system of claim 1, further comprising a syringe housing at least one additive, the syringe attached to the proximal end of the insertion catheter.

15. The system of claim 1, wherein the light-conducting fiber is modified to alter a direction of a light.

16. The system of claim 1, wherein at least one of the insertion catheter, outer expandable portion or the inner expandable portion includes one or more radiopaque markers.

17. The system of claim 1, wherein the textured surface includes at least one of bumps, riblets, ribs, and ridges.

18. A photodynamic bone stabilization and drug delivery system for repairing a fractured bone comprising:

an insertion catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, the insertion catheter having an inner void for passing at least one light-sensitive liquid, and an inner lumen;

an expandable portion releasably engaging the distal end of the insertion catheter, wherein the expandable portion comprises;

an inner expandable portion in communication with the inner lumen of the insertion catheter and sufficiently designed to maintain a light-sensitive liquid within the inner expandable portion; and

an outer expandable portion, surrounding the inner expandable portion, sufficiently designed to house and release at least one additive from the outer expandable portion in an outward direction from the inner expandable portion, wherein the outer expandable portion includes one or more porous sections designed to release the at least one additive into an intramedullary canal of the fractured bone; and

a light-conducting fiber, wherein the light-conducting fiber is sized to pass through the inner lumen of the insertion catheter and into the inner expandable portion for delivering light energy to the light-sensitive liquid to cure the light-sensitive liquid within the inner expandable portion,

wherein at least one of an outer surface of the inner expandable portion or an inner surface of the outer expandable portion includes a textured surface.

19. The system of claim 18, wherein the one or more porous sections are designed to release the at least one additive from the outer expandable portion at a pre-determined flow.

20. A photodynamic bone stabilization and drug delivery system for repairing a fractured bone comprising:

an insertion catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, the insertion catheter having an inner void for passing at least one light-sensitive liquid, and an inner lumen;

an expandable portion releasably engaging the distal end of the insertion catheter, wherein the expandable portion comprises;

a thin-walled non-compliant inner expandable portion in communication with the inner lumen of the insertion catheter sufficiently designed to stabilize the fractured bone, wherein the inner expandable portion is sufficiently designed to maintain a light-sensitive liquid within the inner expandable portion; and

a thin-walled non-compliant outer expandable portion, surrounding the inner expandable portion, sufficiently designed to release at least one additive housed between the inner expandable portion and the outer expandable portion into an intramedullary canal of the fractured bone; and

a light-conducting fiber, wherein the light-conducting fiber is sized to pass through the inner lumen of the insertion catheter and into the inner expandable portion for delivering light energy to the light-sensitive liquid to cure the light-sensitive liquid within the inner expandable portion,

wherein at least one of an outer surface of the inner expandable portion or an inner surface of the outer expandable portion includes a textured surface.