Method of a pharmaceutical delivery system for use within a joint replacement

• US 8,685,106 B2
• Filed: 03/01/2012
• Issued: 04/01/2014
• Est. Priority Date: 11/15/2011
• Status: Active Grant

• Current Assignee: Arthrovance, Inc.
• Original Assignee: Arthrovance, Inc.
• Inventors: Lin, Abraham, Li, Jiunyih
• Primary Examiner(s): STEWART, JASON-DENNIS NEILKEN
• Application Number:
  US13/409,114
• Publication Number:
  US 20130123742A1
• Time in Patent Office: 761 Days
• Field of Search: 623/11.11, 623/16.11, 623/17.11, 623/17.12, 623 2014- 2016, 623/22.11, 623 2357- 2359
• US Class Current: 623/22.11
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 5/00 Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests vaccination appliances for veterinary use A61D1/025 ; tube connectors, tube couplings, valves or branch units specially adapted for medical use A61M39/00; containers specially adapted for medical or pharmaceutical purposes A61J1/00; combinations of vial and syringe for mixing or transferring their contents A61J1/20; holders for containers for collecting, storing or administering blood or medical fluids A61J1/16
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

Methods and apparatus of providing a joint replacement parts with a pharmaceutical delivery system is provided. The pharmaceutical delivery system is placed within the joint replacement parts to provide, over a period of time, sustained release of a controlled concentration of pharmaceuticals within the joint space of the joint replacement and to produce a local or systemic physiological of pharmacological effect.

Claims

1. A drug delivery system for the sustained administration of a pharmaceutical into a joint replacement at a controlled rate to produce a beneficial response, said device comprising:

a. a body comprising at least one portion of pharmaceutical mixed with at least one portion of polymer;

b. a joint replacement is drilled to cause an opening to accommodate said body;

c. wherein said body is placed inside said opening without interfering with said joint replacement'"'"'s normal operation;

d. a membrane sealing said body within said opening;

e. wherein said membrane is comprised of a material which allows for said pharmaceutical to diffuse across said membrane;

f. wherein said material further determines the diffusion rate of said pharmaceutical crossing said membrane, wherein said pharmaceutical is an antibiotic, wherein said joint replacement is a hip replacement, wherein said body is further held within said opening with a press fit.

2. The drug delivery system of claim 1 wherein said beneficial response is a pharmacological response.

3. The drug delivery system of claim 1 wherein said beneficial response is physiological response.

4. The drug delivery system of claim 1 wherein said opening is located at an non weight bearing area of said insert.

5. The drug delivery system of claim 1 wherein said pharmaceutical is in a paste form.

6. The drug delivery system of claim 1 wherein said pharmaceutical is in a liquid form.

7. The drug delivery system of claim 1 wherein said body is further held within said opening with a press fit.