Ultra-pasteurization for dialysis machines

• US 8,685,251 B2
• Filed: 12/03/2010
• Issued: 04/01/2014
• Est. Priority Date: 12/05/2009
• Status: Active Grant

• Current Assignee: Outset Medical, Inc.
• Original Assignee: Home Dialysis Plus, Ltd.
• Inventors: Smejtek, Dalibor Jan, Curtis, James R.
• Primary Examiner(s): CECIL, TERRY K
• Application Number:
  US12/960,426
• Publication Number:
  US 20110192796A1
• Time in Patent Office: 1,215 Days
• Field of Search: 210/137, 210/181, 210/652
• US Class Current: 210/652
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1662 with heat exchange between fresh and used dialysate
• CPC Class Codes: A61M 1/1664 with temperature control
• CPC Class Codes: A61M 2206/11 Laminar flow
• CPC Class Codes: B01D 2313/08 Flow guidance means within the module or the apparatus
• CPC Class Codes: B01D 63/085 specially adapted for two fluids in mass exchange flow
• CPC Class Codes: C02F 1/02 by heating methods of steam generation F22B; preheating boiler feed-water or accumulating preheated boiler feed-water F22D
• CPC Class Codes: C02F 1/20 by degassing, i.e. liberation of dissolved gases degasification of liquids in general B01D19/00; arrangement of degassing apparatus in boiler feed supply F22D
• CPC Class Codes: C02F 1/283 using coal, charred products, or inorganic mixtures containing them
• CPC Class Codes: C02F 1/441 by reverse osmosis
• CPC Class Codes: C02F 1/444 by ultrafiltration or microfiltration
• CPC Class Codes: C02F 2103/026 Treating water for medical or cosmetic purposes
• CPC Class Codes: C02F 2209/03 Pressure
• CPC Class Codes: C02F 2209/05 Conductivity or salinity
• CPC Class Codes: C02F 2303/04 Disinfection
• CPC Class Codes: C02F 9/20 Portable or detachable small-scale multistage treatment devices, e.g. point of use or laboratory water purification systems
• CPC Class Codes: F28D 2021/005 for medical applications
• CPC Class Codes: F28D 9/0043 the plates having openings therein for circulation of at least one heat-exchange medium from one conduit to another
• CPC Class Codes: F28D 9/0093 Multi-circuit heat-exchangers, e.g. integrating different heat exchange sections in the same unit or heat-exchangers for more than two fluids
• CPC Class Codes: F28F 2225/04 : for conduits
• CPC Class Codes: F28F 2250/102 : with change of flow direction
• CPC Class Codes: F28F 2260/02 : having microchannels
• CPC Class Codes: F28F 3/048 : in the form of ribs integral with the element or local variations in thickness of the element, e.g. grooves, microchannels

Abstract

Disclosed herein are water purification and supply systems for medical devices and methods of using. In an embodiment, the system includes a dialysis system including a filtration system capable of filtering a water stream, a water purification system capable of purifying the water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream. The water purification system includes an RO filter 6122, a proportioning valve 6165, a heater 6150, first and second heat exchangers, and a throttle valve 6160.

Claims

1. A water purification and supply system for a medical device, the system comprising:

a reverse-osmosis filter with a water inlet, a filtered water outlet, and a filter waste water outlet;

a pump in fluid communication with and downstream from the filtered water outlet;

a first heat exchanger having a filtered water inlet, a filtered water outlet, a waste water inlet and a waste water outlet, the filtered water inlet in fluid communication with and downstream from the pump, the waste water outlet in fluid communication with a drain;

a heater in fluid communication with and downstream from the filtered water outlet of the first heat exchanger;

a second heat exchanger having a filtered water inlet, a filtered water outlet, a waste water inlet, and a waste water outlet, the filtered water inlet in fluid communication with and downstream from the heater, the waste water inlet of the first heat exchanger in fluid communication with and downstream from the waste water outlet of the second heat exchanger;

a throttle valve in fluid communication with and downstream from the filtered water outlet of the second heat exchanger; and

a proportioning valve having a valve inlet, a first valve outlet and a second valve outlet, the valve inlet in communication with and downstream from the filter waste water outlet, the second valve outlet in communication with the drain, the first valve outlet in fluid communication with the waste water inlet of the second heat exchanger.

2. The system of claim 1, wherein waste water flows through the first heat exchanger between the waste water inlet and the waste water outlet in a first direction.

3. The system of claim 2, wherein filtered water flows through the first heat exchanger between the filtered water inlet and the filtered water outlet in a second direction, wherein the second direction is opposite to the first direction.

4. The system of claim 3, wherein the waste water and filtered water are in thermal communication within the first heat exchanger.

5. The system of claim 4, wherein waste water flows through the second heat exchanger between the waste water inlet and the waste water outlet in a first direction.

6. The system of claim 5, wherein filtered water flows through the second heat exchanger between the filtered water inlet and the filtered water outlet in a second direction, wherein the second direction is opposite to the first direction.

7. The system of claim 6, wherein the waste water and filtered water are in thermal communication within the second heat exchanger.

8. The systems of claim 7, wherein the waste water from the second heat exchanger warms the filtered water within the first heat exchanger before the filtered water enters the heater.

9. The system of claim 8, wherein the waste water cools the filtered water within the second heat exchanger before the filtered water enters the throttle valve.

10. A water purification and supply system for a medical device, the system comprising:

a first heat exchanger having a supply water inlet, a supply water outlet, a waste water inlet and a waste water outlet, the waste water outlet in fluid communication with a drain;

a reverse-osmosis filter with a water inlet, a filtered water outlet, and a filter waste water outlet, the water inlet in fluid communication with the supply water outlet of the first heat exchanger;

a fluid pump in fluid communication with and downstream from the filtered water outlet;

a heater in fluid communication with and downstream from the fluid pump;

a second heat exchanger having a filtered water inlet, a filtered water outlet, a waste water inlet, and a waste water outlet, the filtered water inlet in fluid communication with and downstream from the heater, the waste water outlet of the first heat exchanger in fluid communication with and downstream from the waste water inlet of the second heat exchanger;

a throttle valve in fluid communication with and downstream from the filtered water outlet of the second heat exchanger; and

a proportioning valve having a valve inlet, a first valve outlet and a second valve outlet, the valve inlet in communication with and downstream from the filter waste water outlet, the second valve outlet in communication with the drain, the first valve outlet in fluid communication with the waste water inlet of the second heat exchanger.

11. The system of claim 10, wherein supply water flows through the first heat exchanger between the supply water inlet and the supply water outlet in a first direction.

12. The system of claim 11, wherein waste water flows through the first heat exchanger between the waste water inlet and the waste water outlet in a second direction, wherein the second direction is opposite to the first direction.

13. The system of claim 12, wherein the waste water and supply water are in thermal communication within the first heat exchanger.

14. The system of claim 13, wherein waste water flows through the second heat exchanger between the waste water inlet and the waste water outlet in a first direction.

15. The system of claim 14, wherein filtered water flows through the second heat exchanger between the filtered water inlet and the filtered water outlet in a second direction, wherein the second direction is opposite to the first direction.

16. The system of claim 15, wherein the waste water and filtered water are in thermal communication within the second heat exchanger.

17. The systems of claim 16, wherein the waste water from the second heat exchanger warms the supply water within the first heat exchanger before the supply water enters the reverse-osmosis filter.

18. The system of claim 17, wherein the waste water cools the filtered water within the second heat exchanger before the filtered water enters the throttle valve.

19. The system of claim 10, further comprising:

a dialyzer having a blood flow pathway through which blood flows;

a fluid inlet pathway configured to provide incoming fluid to the dialyzer;

a fluid outlet pathway configured to receive outgoing fluid from the dialyzer;

a first flow balance pump coupled to the fluid inlet pathway and configured to pump the fluid through the fluid inlet pathway toward the dialyzer;

a second flow balance pump coupled to the fluid outlet pathway and configured to pump the fluid through the fluid outlet pathway away from the dialyzer; and

a third flow balance pump coupled to the fluid outlet pathway, the third pump configured to work in cooperation with the second pump to achieve a desired flow rate of fluid to or from the blood flowing through the dialyzer.

20. A method of ultra-pasteurizing water for a dialysate system, comprising:

supplying water to a water inlet of a reverse-osmosis filter;

supplying filtered water from a filtered water outlet and pumping the filtered water to a filtered water inlet of a first heat exchanger;

supplying pre-heated filtered water from the filtered water outlet of the first heat exchanger to a heater;

supplying the heated filtered water from the heater to a filtered water inlet of a second heat exchanger;

supplying cooled water from the filtered water outlet of the second heat exchanger to a throttle valve;

supplying cooled water from the throttle valve to a dialysate handling system;

supplying the waste water from a waste water outlet of the reverse-osmosis filter to a proportioning valve;

controlling the flow of waste water through the proportioning valve to a drain and the waste water inlet of the second heat exchanger;

supplying the waste water from the proportioning valve to the inlet of the second heat exchanger passing the waste water through the second heat exchanger and in thermal communication with the filtered water so as to cool the filtered water;

supplying the waste water from the waste water outlet of the second heat exchanger to the waste water inlet of the first heat exchanger and in thermal communication with the filtered water in the first heat exchanger so as to heat the filtered water prior to the filtered water passing through the heater; and

passing the waste water through the waste water outlet of the first heat exchanger and dumping to the drain.