Tailored aliphatic polyesters for stent coatings
First Claim
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1. A coating on a medical device, comprising a polyester (PE) polymer and a phosphorylcholine (PC) functionalized aliphatic absorbable polymer,wherein the PE polymer is included in a matrix layer comprising a bioactive agent,wherein the phosphorylcholine (PC) functionalized aliphatic absorbable polymer is included in a topcoat of a thickness from about 1 to 2 microns on top of the matrix layer, andwherein the phosphorylcholine (PC) functionalized aliphatic absorbable polymer comprises poly glycerol sebacate.
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Abstract
A aliphatic polyester polymer for stent coating is described.
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10 Claims
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1. A coating on a medical device, comprising a polyester (PE) polymer and a phosphorylcholine (PC) functionalized aliphatic absorbable polymer,
wherein the PE polymer is included in a matrix layer comprising a bioactive agent, wherein the phosphorylcholine (PC) functionalized aliphatic absorbable polymer is included in a topcoat of a thickness from about 1 to 2 microns on top of the matrix layer, and wherein the phosphorylcholine (PC) functionalized aliphatic absorbable polymer comprises poly glycerol sebacate.
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8. A method of forming PC functionalized aliphatic polyester, comprising
polymerizing or copolymerizing lactone monomers that comprise at least one monomer comprising an olefinic or acetylenic functionality α - (alpha) to the carbonyl group of the lactone group to form an aliphatic polyester polymer or copolymer comprising the olefinic or acetylenic functionality,
functionalizing the olefinic or acetylenic functionality in the aliphatic polyester polymer or copolymer to generate a functionalized aliphatic polyester polymer or copolymer, and attaching PC to the functionalized aliphatic polyester polymer or copolymer to generate the PC funtionalized aliphatic polyester; wherein the aliphatic polyester polymer or copolymer comprises poly glycerol sebacate.
- (alpha) to the carbonyl group of the lactone group to form an aliphatic polyester polymer or copolymer comprising the olefinic or acetylenic functionality,
Specification