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Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules

  • US 8,685,755 B2
  • Filed: 07/20/2010
  • Issued: 04/01/2014
  • Est. Priority Date: 07/20/2009
  • Status: Active Grant
First Claim
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1. A method of analyzing a biological sample, the method comprising the steps of:

  • a. providing the sample;

    b. providing a substrate comprising a silica-based mesoporous material, wherein;

    the pores of said mesoporous material have a pre-determined pore morphology;

    a surface of the substrate is functionalized with a phosphate moiety to which an inorganic metal ion is immobilized; and

    the inorganic metal ion is selected from the group consisting of gallium, titanium, and zirconium;

    c. exposing the mesoporous material to the sample such that a fraction of the sample is retained by the mesoporous material; and

    d. analyzing a fraction of the sample retained by the mesoporous material.

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