Noninvasive photoplethysmographic sensor platform for mobile animals

• US 8,688,184 B2
• Filed: 12/08/2008
• Issued: 04/01/2014
• Est. Priority Date: 04/11/2007
• Status: Active Grant

• Current Assignee: STARR Life Sciences Corp.
• Original Assignee: STARR Life Sciences Corp.
• Inventors: Truitt, Patrick, Hete, Bernard F., Starr, Eric W
• Primary Examiner(s): Szmal, Brian
• Assistant Examiner(s): NGUYEN, HUONG Q
• Application Number:
  US12/330,501
• Publication Number:
  US 20090149727A1
• Time in Patent Office: 1,940 Days
• Field of Search: 600/344
• US Class Current: 600/323
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor

Abstract

A noninvasive photoplethysmographic sensor platform for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor platform may be a collar which provides an easily affixed, adjustable attachment mechanism that encircles the animal, such as the neck. The neck of the animal provides several particular advantages as a sensor mounting platform for photoplethysmographic sensors. For pulse oximetry, the neck location will provide significant blood flow under all conditions. For small mammals, such as rats and mice, transmittance pulse oximetry through the neck of the subject remains possible. The neck mounted collar also offers inherent bite resistance to the sensor platform.

Claims

1. A method of obtaining noninvasive photoplethysmographic measurements from an animal, which is a mouse or a rat, comprising the steps of:

Providing a body encircling base configured to encircle one of the head, neck, chest or abdomen portion of the body of a subject animal, which is a mouse or a rat, the base including an emitter on the body configured to be mounted adjacent the subject animal, the emitter having two light sources of distinct wavelength, and a receiver on the body configured to be mounted adjacent the subject animal for detecting light from the emitter that has been toward tissue of the subject animal;

Securing the base in a position encircling one of the head, neck, chest or abdomen portion of the body of a subject animal, which is a mouse or a rat;

Obtaining photoplethysomgraphic measurements from the receiver on the base on the subject animal which is a mouse or a rat.

2. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 wherein the animal is an anesthetized rat or an anesthetized mouse.

3. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 wherein the base is secured around the neck of the animal.

4. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 wherein the base is secured around the chest of the animal.

5. The method of obtaining noninvasive photoplethysmographic measurements according to claim 4 further including providing additional sensors at a location other than the base making a normal systemic arterial saturation measurements, and calculating an A-V gradient about the subject animals heart.

6. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 further including the step of obtaining further physiologic measurements from at least one additional sensor mounted on the base.

7. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 wherein the base is secured around the head of the animal.

8. The method of obtaining noninvasive photoplethysmographic measurements according to claim 7 wherein the emitter is adjacent the eyes of the animal.

9. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 wherein the body encircling base is formed as a neck collar clip secured around the neck of the animal.

10. The method of obtaining noninvasive photoplethysmographic measurements according to claim 9 wherein the neck collar clip has two halves coupled together at a pivot pin.

11. The method of obtaining noninvasive photoplethysmographic measurements according to claim 1 further including the step of calculating an A-V gradient about the subject animals heart.

12. The method of obtaining noninvasive photoplethysmographic measurements according to claim 11 wherein the animal is an anesthetized rat or an anesthetized mouse.

13. The method of obtaining noninvasive photoplethysmographic measurements according to claim 11 further including a transmitter on the base coupled to the emitter and the receiver.