System and method to monitor ejection time and QT interval to alert patients before syncopal events

• US 8,688,201 B2
• Filed: 04/24/2008
• Issued: 04/01/2014
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Corbucci, Giorgio, Boute, Willem, Scholten, Patrick, Smit, Josephus P. A.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): OROPEZA, FRANCES P
• Application Number:
  US12/108,745
• Publication Number:
  US 20090270748A1
• Time in Patent Office: 2,168 Days
• Field of Search: 600/373, 600/374, 600/508, 600/509, 600/513
• US Class Current: 600/513
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/36 Detecting PQ interval, PR interval or QT interval
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An implantable medical device and associated method predict syncope based on detecting a change in ejection time. A physiological signal is sensed that is responsive to mechanical changes associated with the cardiac ejection phase. A time interval corresponding to cardiac ejection time is detected from the physiological signal. A sudden change in the time interval is used as a predictor of syncope and causes a patient alert to be generated in response to the detected change.

Claims

1. A method for predicting syncope for use in an implantable medical device, comprising:

sensing a physiological signal;

determining a time interval corresponding to cardiac ejection time from the physiological signal;

detecting a change in the time interval;

predicting syncope in response to the detected change; and

generating a patient alert in response to the predicted syncope.

2. The method of claim 1, wherein sensing the physiological signal comprises sensing a signal responsive to an arterial pulse.

3. The method of claim 2 wherein sensing the signal comprises sensing a motion of an arterial wall.

4. The method of claim 3 wherein determining the time interval comprises detecting a first acceleration signal corresponding to aortic valve opening and detecting a second acceleration signal corresponding to aortic valve closure.

5. The method of claim 4 further comprising:

sensing an ECG signal;

determining a QT interval from the ECG signal;

determining a ratio of the time interval to the QT interval; and

wherein detecting a change in the time interval comprises detecting a change in the ratio of the time interval to the QT interval.

6. The method of claim 4 further comprising:

sensing a signal corresponding to an onset of an isovolumic contraction of the heart;

determining a second time interval beginning at a time corresponding to the onset of the isovolumic contraction of the heart;

detecting a change in the second time interval; and

predicting syncope in response to the detected change in the second time interval.

7. The method of claim 6 wherein sensing the signal corresponding to an onset of isovolumic contraction comprises one of sensing a QRS complex and a first heart sound.

8. The method of claim 7 wherein the second time interval ends at a time corresponding to one of the first acceleration signal and the second acceleration signal.

9. The method of claim 1 wherein detecting the change in the time interval comprises detecting a change occurring in less than about two minutes.

10. The method of claim 1 further comprising:

sensing a signal responsive to changes in a patient posture;

wherein predicting syncope comprises predicting syncope in response to the detected change in the time interval when a patient posture change is absent.

11. The method of claim 1 further comprising:

sensing an ECG signal;

determining a QT interval from the ECG signal;

determining a physiological limit in response to the QT interval;

wherein detecting a change in the time interval comprises detecting the time interval crossing the physiological limit.

12. An implantable medical device system for predicting syncope, comprising:

a sensor for sensing a physiological signal;

a processor configured to receive the sensor signal, determine a time interval corresponding to a cardiac ejection time from the physiological signal, detect a change in the time interval, and predict syncope in response to the detected change in the time interval; and

a patient alert module for generating a patient alert in response to the predicted syncope.

13. The device of claim 12, wherein the sensor comprises a sensor responsive to an arterial pulse.

14. The device of claim 13 wherein the sensor comprises an accelerometer sensitive to motion of an arterial wall.

15. The device of claim 14 wherein the processor determining the time interval detects a first acceleration signal corresponding to aortic valve opening and detects a second acceleration signal corresponding to aortic valve closure.

16. The device of claim 15 further comprising:

an electrode for sensing an ECG signal;

wherein the processor receives the ECG signal and determines a QT interval from the ECG signal, determines a ratio of the time interval to the QT interval, detects a change in the ratio of time interval to the QT interval, and predicts syncope in response to the detected changed ratio.

17. The device of claim 15 further comprising:

a sensor for sensing a signal corresponding to an onset of isovolumic contraction of the heart,

the processor further configured to determine a second time interval beginning at a time corresponding to the onset of isovolumic contraction of the heart, detect a change in the second time interval, and predict syncope in response to the detected change in the second time interval.

18. The device of claim 17 wherein the sensor for sensing a signal corresponding to an onset of isovolumic contraction comprises one of an ECG sensing electrode and an acoustical sensor responsive to the first heart sound.

19. The device of claim 18 wherein the second time interval ends at a time corresponding to one of the first acceleration signal and the second acceleration signal.

20. The device of claim 12 further comprising:

a sensor responsive to changes in patient posture;

the processor further configured to detect a change in patient posture and predict syncope in response to the detected change in the time interval when a patient posture change is absent.

21. The device of claim 12 further comprising:

an electrode for sensing an ECG signal;

wherein the processor is further configured to determine a QT interval from the ECG signal, determine a physiological limit in response to the QT interval, and detect a crossing of the physiological limit by the time interval as a change in the time interval.

22. The device of claim 12 wherein the processor detects the change in the time interval by detecting a change occurring in up to about two minutes.

23. A non-transitory computer readable medium for storing a set of instructions for predicting syncope, which, when implemented in an implantable medical device system, cause the system to:

sense a physiological signal;

detect a time interval corresponding to cardiac ejection time from the physiological signal;

detect a change in the time interval;

predict syncope in response to the changed time interval; and

generate a patient alert in response to the predicted syncope.