Device for ambulatory monitoring of brain activity

• US 8,688,209 B2
• Filed: 09/19/2007
• Issued: 04/01/2014
• Est. Priority Date: 09/25/2006
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Verbitskiy, Evgeny
• Primary Examiner(s): Matthews, Christine
• Assistant Examiner(s): Reddy, Sunita
• Application Number:
  US12/442,558
• Publication Number:
  US 20100010364A1
• Time in Patent Office: 2,386 Days
• Field of Search: 600/544, 600/382, 600/390, 600/545
• US Class Current: 600/544
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

A device for ambulatory monitoring of brain activity includes a patch secured to a head of a monitoring subject and an electrode secured to the head of the monitoring subject. The electrode produces a signal indicating brain activity of the monitoring subject. The device further includes a signal processor that receives the signal produced by the electrode and processes the signal to produce data. The signal processor is secured to the monitoring subject. The device further includes a display that displays the data produced by the signal processor, the display being secured to the monitoring subject. The device also includes a power source secured to the monitoring subject, the power source providing power to the electrode, the signal processor, and the display wherein the monitoring subject may ambulate unimpeded by the patch, the electrode, the signal processor, the display and the power source.

Claims

1. A device for ambulatory monitoring of brain activity, comprising:

a plurality of electrodes adapted to be operatively secured to a head of a monitoring subject, each electrode producing a signal indicating brain activity of the monitoring subject;

a signal processor that receives the signals produced by the plurality of electrodes and processes the signals to produce data, the signal processor adapted to be secured to the monitoring subject and analyzing the signals such that the signal processor determines an occurrence of a brain spike based on a) a convolved signal that exceeds a first fixed threshold and b) coefficients determined from wavelet decomposition that exceed a second fixed threshold;

a display that displays the data produced by the signal processor, the display adapted to be secured to the monitoring subject; and

a power source adapted to be secured to the monitoring subject, the power source providing power to the plurality of electrodes, the signal processor, and the display,

wherein the monitoring subject may ambulate unimpeded by the plurality of electrodes, the signal processor, the display and the power source.

2. The device according to claim 1, further comprising a communication port for transferring the data to a remote device.

3. The device according to claim 1, further comprising a strap adapted to be disposed around the head of the monitoring subject.

4. The device according to claim 3, wherein the plurality of electrodes are integral to the strap.

5. The device according to claim 1, further comprising a patch adapted to be attached to the head of the monitoring subject, wherein the plurality of electrodes are integral to the patch.

6. A method of ambulatory monitoring of brain activity, comprising:

operatively securing a plurality of electrodes to the head of the monitoring subject;

securing a signal processor to the monitoring subject;

securing a display to the monitoring subject;

securing a power source to the monitoring subject;

providing power from the power source to the plurality of electrodes, the signal processor, and the display;

producing signals indicating brain activity of the monitoring subject;

transmitting the signals from the plurality of electrodes to the signal processor;

analyzing the signals to determine a period of time when an absence or reduction in the number of neural spikes is measured to determine whether a neurological seizure event is imminent,

producing data based on the period of time;

displaying the data on the display, wherein the monitoring subject may ambulate unimpeded by the plurality of electrodes, the signal processor, the display and the power source.

7. The method according to claim 6, further comprising transferring the data from a communications port to a remote device.

8. The method according to claim 7, further comprising securing a strap around the head of the monitoring subject.

9. The method according to claim 8, wherein the plurality of electrodes are integral to the strap.

10. The method according to claim 6, wherein analyzing includes implementing a filter in the time domain.

11. The method according to claim 6, wherein analyzing includes implementing a filter in the frequency domain.

12. The method according to claim 6, wherein analyzing includes implementing a filter based on a wavelet coefficient.

13. The method according to claim 6, wherein analyzing includes implementing a matched filter in the frequency domain and the time domain.

14. The method according to claim 6, wherein analyzing includes convolving the signals.

15. The method according to claim 6, wherein analyzing includes comparing a value to a predetermined threshold.

16. The method according to claim 6, wherein analyzing includes analyzing the signals from the plurality of electrodes and identifying the occurrence of brain spike only if the brain spike is indicated as being present based on the analysis of each of the signals.

17. The method according to claim 6, wherein analyzing includes counting a number of brain spikes.

18. The method according to claim 6, wherein analyzing includes analyzing clusters of brain spikes.

19. The method according to claim 6, wherein analyzing includes analyzing the signals as a function of time.

20. The method according to claim 6, further comprising issuing an alarm when a result of the analysis satisfies a predetermined alarm condition.

21. A method of ambulatory monitoring of brain activity, comprising:

providing power from a power source secured to a monitoring subject to a plurality of electrodes operatively secured to a head of the monitoring subject, a signal processor secured to the monitoring subject, and a display secured to the monitoring subject;

producing signals indicating brain activity of the monitoring subject;

transmitting the signals from the plurality of electrodes to the signal processor;

analyzing the signals to determine a period of time when an absence or reduction in the number of neural spikes is measured to determine whether a neurological seizure event is imminent,

producing data based on the period of time;

displaying the data on the display, wherein the monitoring subject may ambulate unimpeded by the plurality of electrodes, the signal processor, the display and the power source.