Cardiac cycle synchronized sampling of impedance signal

• US 8,688,214 B2
• Filed: 05/10/2013
• Issued: 04/01/2014
• Est. Priority Date: 07/02/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kim, Jaeho, Ni, Quan
• Primary Examiner(s): Porter, Jr., Allen
• Application Number:
  US13/891,318
• Publication Number:
  US 20130253340A1
• Time in Patent Office: 326 Days
• Field of Search: 607 2- 9, 607/17, 607/18, 607/42, 600/533, 600/547
• US Class Current: 607/18
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

A system comprising implantable device, the implantable medical device including an intrinsic cardiac signal sensor, an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, and a processor coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit. The processor is configured to initiate sampling of a transthoracic voltage signal in a specified time relation to a fiducial marker in a sensed intrinsic cardiac signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal, and determine lung respiration using the sampled transthoracic voltage signal.

Claims

1. A system comprising implantable device, the implantable medical device including:

an intrinsic cardiac signal sensor;

an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, wherein the impedance measurement circuit is configured to measure the transthoracic voltage using a transthoracic measurement vector that includes a ventricle of the subject; and

a processor, coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit, the processor configured to initiate sampling of a transthoracic voltage signal synchronous to an occurrence of a fiducial marker in a sensed intrinsic cardiac signal to preserve a respiratory component of the transthoracic signal and to determine lung ventilation using the respiratory component of the transthoracic voltage signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal.

2. The system of claim 1, wherein the processor is configured to determine transthoracic impedance and wherein the sampling attenuates or removes variation of transthoracic impedance with cardiac stroke volume.

3. The system of claim 1, including a therapy circuit configured to provide a therapy to treat sleep apnea, wherein the processor is configured to determine respiratory activity using the sampled transthoracic voltage signal and initiate therapy to treat sleep apnea when the determined respiratory activity falls below a predetermined level.

4. The system of claim 1, wherein the

fiducial marker includes an R-wave in the sensed intrinsic cardiac signal.

5. The system of claim 1, wherein the processor is configured to:

initiate sampling to produce a sampled transthoracic voltage signal having a cardiac stroke volume signal component that has a substantially constant value;

convert sampled transthoracic voltage signal values to transthoracic impedance values; and

calculate lung ventilation using the transthoracic impedance values.

6. The system of claim 1,

wherein the transthoracic voltage signal includes a cardiac stroke volume component having a first frequency and includes a low frequency component having a second frequency lower than the first frequency;

wherein the processor is configured to;

initiate sampling to preserve a low frequency component of the transthoracic voltage signal; and

convert the low frequency component of the transthoracic voltage signal to a low frequency component of a transthoracic impedance signal.

7. The system of claim 1, wherein the impedance measurement circuit is configured to sample an unfiltered transthoracic voltage signal.

8. The system of claim 1, including:

a memory integral to or electrically coupled to the processor, wherein the processor is configured to;

store a sampled value of transthoracic voltage in a synchronous relation to the occurrence of the fiducial marker in the sensed intrinsic cardiac signal, and

increase a rate of storing sampled values of transthoracic voltage as the rate of occurrence of the fiducial marker increases.

9. A system comprising implantable device, the implantable medical device including:

an intrinsic cardiac signal sensor;

an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current wherein the impedance measurement circuit is configured to measure the transthoracic voltage using a transthoracic measurement vector that includes an atrium of the subject; and

a processor, coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit, the processor configured to initiate sampling of a transthoracic voltage signal synchronous to an occurrence of a fiducial marker in a sensed intrinsic cardiac signal to preserve a respiratory component of the transthoracic signal and to determine lung ventilation using the respiratory component of the transthoracic voltage signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal.

10. A method comprising:

applying a specified current to a transthoracic region of a subject;

sampling a transthoracic voltage signal resulting from the specified current using a transthoracic measurement vector that includes a ventricle of the subject, wherein the sampling occurs synchronously to an occurrence of a fiducial marker in a sensed intrinsic cardiac signal that preserves a respiratory component of the transthoracic signal and attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal; and

determining lung ventilation using the respiratory component of the transthoracic voltage signal.

11. The method of claim 10, including determining transthoracic impedance;

and attenuating or removing, by the sampling, variation of transthoracic impedance with cardiac stroke volume.

12. The method of claim 10, including determining respiratory activity using the sampled transthoracic voltage signal;

and initiating therapy to treat sleep apnea when the determined respiratory activity falls below a predetermined level.

13. The method of claim 10, including:

initiating sampling to produce a sampled transthoracic voltage signal having a cardiac stroke volume signal component that has a substantially constant value;

converting sampled transthoracic voltage signal values to transthoracic impedance values; and

calculating lung ventilation using the transthoracic impedance values.

14. The method of claim 10, wherein the sampling synchronously to an occurrence of a fiducial marker includes sampling the transthoracic voltage signal synchronously with an occurrence of an R-wave in the sensed intrinsic cardiac signal.

15. The method of claim 10,

wherein the transthoracic voltage signal includes a cardiac stroke volume component having a first signal frequency and includes a low frequency component having a second signal frequency lower than the first signal frequency,

wherein sampling a transthoracic voltage signal includes sampling to preserve a low frequency component of the transthoracic voltage signal, and

wherein the method includes converting the low frequency component of the transthoracic voltage signal to a low frequency component of a transthoracic impedance signal.

16. The method of claim 10, wherein sampling a transthoracic voltage signal includes storing a sampled value of transthoracic voltage in a synchronous relation to the fiducial marker in the sensed intrinsic cardiac signal.

17. The method of claim 10,

wherein applying a specified current and sampling a transthoracic voltage signal includes applying the specified current and sampling the transthoracic voltage signal using a first combination of electrodes, and

wherein the method includes changing, in response to determining signal noise in the transthoracic voltage signal, to a second combination of electrodes for applying the specified current and sampling the transthoracic impedance.

18. The method of claim 10, wherein a frequency of occurrence of the fiducial marker in the cardiac signal increases with heart rate of the subject, and wherein sampling a transthoracic voltage signal includes increasing a sampling frequency of the transthoracic voltage signal with the increase in heart rate.

19. The method of claim 10, including determining that lung respiration is below a specified lung respiration level;

and initiating delivery of diaphragmatic pacing in response to the determination.