Devices, methods, and systems including cardiac pacing

• US 8,688,234 B2
• Filed: 12/18/2009
• Issued: 04/01/2014
• Est. Priority Date: 12/19/2008
• Status: Active Grant

• Current Assignee: Newstim, Inc.
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, Ortega, Daniel Felipe, Spinelli, Julio Cesar
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US13/139,951
• Publication Number:
  US 20120101539A1
• Time in Patent Office: 1,565 Days
• Field of Search: 607/4, 607/119
• US Class Current: 607/119
• CPC Class Codes: A61N 1/0565 Electrode heads
• CPC Class Codes: A61N 1/0573 chacterised by means penetrating the heart tissue, e.g. helix needle or hook
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A pacing output circuit can be configured to generate a ventricular pacing signal configured to be delivered to an electrode near the His bundle in a right ventricle of a heart to pace the right and left ventricles and improve synchronization of at least one of the ventricles relative to intrinsic activity. In an example, the ventricular pacing signal can include first and second signal components in opposite polarity from each other with respect to a reference component, the first and second signal components having substantially identical duration and magnitude.

Claims

1. An apparatus comprising:

a pacing output circuit configured to generate a ventricular pacing signal to deliver to an electrode near the His bundle in a right ventricle of a heart to pace the right and left ventricles and improve synchronization of at least one of the ventricles relative to intrinsic activity, the pacing output circuit comprising;

a first terminal, configured to deliver a first signal component;

a second terminal, configured to deliver a second signal component;

a third terminal, configured to deliver a reference signal component; and

wherein the first and second signal components are provided in opposite polarity from each other with respect to the reference signal component,

wherein the pacing output circuit is configured to recurrently reverse polarity of the first and second signal components from a first polarity arrangement to a second polarity arrangement,

wherein the polarity of the first and second signal components is reversed from the first polarity arrangement to the second polarity arrangement after N beats or time corresponding to the N beats,

wherein the polarity of the first and second signal components is reversed again from the second polarity arrangement to the first polarity arrangement after M beats or time corresponding to the M beats, and wherein N is greater than M.

2. The apparatus of claim 1, further comprising a pacing lead configured to deliver an electrode near the His bundle in a right ventricle of a heart.

3. The apparatus of claim 1, wherein the pacing output circuit is configured to provide the opposite polarity first and second signal components at least partially overlapping in time.

4. The apparatus of claim 1, comprising a cardiac function sensor configured to provide information used to control reversing polarity of the first and second signal components by the pacing output circuit.

5. The apparatus of claim 1, comprising:

an atrial sensing circuit, configured to sense atrial heart contractions;

a controller circuit, configured to determine a paced AV delay, and to time the paced AV delay from an atrial heart contraction, wherein the controller includes a temporary mode in which the paced AV delay is set to a value that is specified to provide a reduced cardiac output relative to a maximum cardiac output while the pacing output circuit provides the ventricular pacing signal to deliver to an electrode near the His bundle in a right ventricle of a heart to pace the right and left ventricles and improve synchronization of at least one of the ventricles relative to intrinsic activity.

6. The apparatus of claim 5, wherein the paced AV delay is set to a value that allows mitral valve closure before completion of a left atrial contraction.

7. The apparatus of claim 6, wherein the paced AV delay is increased after a period of time specified to allow for the heart to recover at the reduced cardiac output.

8. The apparatus of claim 1, in combination with a guide catheter configured for pace-mapping in a right ventricle at or near the His bundle.

9. The apparatus of claim 1 comprising:

a ventricular heart contraction sensing circuit; and

a controller circuit, coupled to the ventricular heart contraction sensing circuit, configured to use information from the ventricular heart contraction sensing circuit to detect a tachyarrhythmia and, in response to the detected tachyarrhythmia, to control the pacing output circuit to deliver the ventricular pacing signal as an anti-tachyarrhythmnia pacing (ATP) pulse to an electrode near the His bundle in a right ventricle of a heart.

10. The apparatus of claim 9, comprising:

a defibrillation shock circuit, coupled to the controller circuit; and

wherein the controller circuit is configured to deliver a defibrillation shock when a plurality of the ATP pulses do not restore the tachyarrhythmia to a non-tachyarrhythmia heart rhythm.

11. The apparatus of claim 10, wherein the controller circuit is configured for controlling the pacing output circuit for:

using at least a first electrode in a right ventricle of the heart for delivering energy relative to a reference electrode;

generating a pacing signal, responsive to depolarization of an atrium of the heart, including a first signal component and a second signal component having opposite polarity; and

transmitting, at a pacing rate sufficient for anti-tachycardia pacing (ATP), said first signal component and said second component to said at least a first electrode and, in response thereto, capturing a contraction of a left ventricle of the heart where the contraction is a more rapid and uniform activation than an right ventricular apex ATP pulse.

12. The apparatus of claim, 1, comprising:

a cardiac function monitor; and

a controller circuit, coupled to the cardiac function monitor and the pacing output circuit, wherein the controller circuit is configured to determine a desired pacing parameter at least in part by iteratively modifying at least one pacing parameter of the pacing output circuit using information received from the cardiac function monitor.

13. The apparatus of claim 1, comprising:

a cardiac function monitor; and

a controller circuit, coupled to the cardiac function monitor and the pacing output circuit, wherein the controller circuit is configured to determine a desired pacing parameter at least in part using information received from the cardiac function monitor regarding at least one of a pacing output amplitude, a QRS width, an AV delay, a pulse pressure, a movement of the patient, a change in blood pressure per time (dP/dt), intraventricular pressure, or a surrogate end-diastolic pressure from a pulmonary artery or vein during pacing of the heart.

14. The apparatus of claim 12, wherein the controller circuit is configured to determine the desired pacing parameter at least in part using gradient capture responsiveness information received from the cardiac function monitor.

15. A method comprising:

generating a ventricular pacing signal to deliver to an electrode near the His bundle in a right ventricle of a heart to pace the right and left ventricles and improve synchronization of at least one of the ventricles relative to intrinsic activity, wherein the pacing signal comprises a first component and a second component of opposite polarity from the first component with respect to a reference signal;

recurrently reversing the polarity of the first and second signal components from a first polarity arrangement to a second polarity arrangement, wherein the recurrently reversing the polarity includes reversing from the first polarity arrangement to the second polarity arrangement after N beats or time corresponding to the N beats, reversing again from the second polarity arrangement to the first polarity arrangement after M beats or time corresponding to the M beats, wherein N and greater than M, and N includes two or more beats.

16. The method of claim 15, further comprising:

determining a paced AV delay, wherein the paced AV delay is timed from an atrial heart contraction, and wherein the paced AV delay is reduced to provide a reduced cardiac output relative to a maximum cardiac output while the pacing signal delivers the ventricular pacing signal to deliver to an electrode near the His bundle in a right ventricle of a heart to pace the right and left ventricles and improve synchronization of at least one of the ventricles relative to intrinsic activity.

17. The method of claim 16, wherein the paced AV delay is increased after a period of time specified to allow for the heart to recover at the reduced cardiac output.

18. The method of claim 16, further comprising increasing the paced AV delay after a period of time specified to allow for the heart to recover at the reduced cardiac output.