Methods and systems for improved pharmaceutical intervention in coagulation control
First Claim
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1. A method of predicting INR or a desirable dosage of a drug in anticoagulant therapy in a patient, comprising:
- providing a coagulation calculator;
configuring the coagulation calculator to perform a calculation operation where logit (1/INR)=−
log (INR−
1) is used as a dependent variable and to produce a result based on the calculation operation;
wherein INR is equal to (PTpt/PTnorm)ISI, wherein PTpt is the patient'"'"'s prothrombin time measured in seconds, PTnorm is the prothrombin time for a pool of normal, untreated plasma, and ISI characterizes a reactivity of a thromboplastin; and
further configuring the coagulation calculator to allow presentation of a result of the calculation operation.
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Abstract
Contemplated methods and devices for coagulation control allow to establish a more constant dosage of required medication and to quantify/take into account patient-specific sensitivity to warfarin and Vitamin K by using logit (1/INR) as the dependent variable to so stabilize the variance across all values of INR. Moreover, it should be noted that such use simplifies the relation between INR and dose of coumarins or Vitamin K and reduces the number of parameters to be estimated for each patient.
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15 Claims
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1. A method of predicting INR or a desirable dosage of a drug in anticoagulant therapy in a patient, comprising:
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providing a coagulation calculator; configuring the coagulation calculator to perform a calculation operation where logit (1/INR)=−
log (INR−
1) is used as a dependent variable and to produce a result based on the calculation operation;wherein INR is equal to (PTpt/PTnorm)ISI, wherein PTpt is the patient'"'"'s prothrombin time measured in seconds, PTnorm is the prothrombin time for a pool of normal, untreated plasma, and ISI characterizes a reactivity of a thromboplastin; and further configuring the coagulation calculator to allow presentation of a result of the calculation operation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A coagulation calculator, comprising:
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a memory element functionally coupled to a processor, an input module, and an output module; wherein the memory element stores software instructions to perform a calculation operation in which logit (1/INR)=−
log (INR−
1) is used as a dependent variable;wherein the software instructions further allow prediction of INR or a desirable dosage of a drug in anticoagulant therapy in a patient using the calculation operation; wherein INR is equal to (PTpt/PTnorm)ISI, wherein PTpt is the patient'"'"'s prothrombin time measured in seconds, PTnorm is the prothrombin time for a pool of normal, untreated plasma, and ISI characterizes a reactivity of a thromboplastin; wherein the processor is configured to execute the software instructions to so produce a result; and wherein the output module is configured to allow presentation of the result. - View Dependent Claims (12, 13, 14, 15)
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Specification