System and method for identifying a prospective clinical therapy for a prospective patient having a medical device

• US 8,688,469 B2
• Filed: 10/29/2010
• Issued: 04/01/2014
• Est. Priority Date: 10/29/2010
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ziegler, Paul D., Sarkar, Shantanu, Redemske, Jodi L.
• Primary Examiner(s): Patel, Neha
• Application Number:
  US12/915,945
• Publication Number:
  US 20120109675A1
• Time in Patent Office: 1,250 Days
• Field of Search: 705/2, 705/3
• US Class Current: 705/2
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 40/60 for the operation of medical equipment or devices

Abstract

System and method for identifying a prospective clinical therapy for a prospective patient. The patient has a medical device, performed with a medical apparatus. The system has a historical database and an analyzer. The historical database incorporates information relating to a multiplicity of patients, each of the multiplicity of patients having a medical device and each of the multiplicity of patients having undergone a clinical therapy, the information including, for each of the multiplicity of patients, device characteristics of the medical device and an assessment of efficacy of clinical therapy. The analyzer correlates device characteristics of the prospective patient with the device characteristics and the assessment of efficacy of clinical therapy of the multiplicity of patients using the historical database to identify a prospective clinical therapy for the prospective patient associated with the device characteristics in the historical database having a relatively greater efficacy than the clinical therapy.

Claims

1. A system for identifying a prospective clinical therapy for a prospective patient having a medical device, performed with a medical apparatus, comprising:

A data storage device configured to store a historical database incorporating information relating to a multiplicity of patients, each of said multiplicity of patients having a medical device and each of said multiplicity of patients having undergone at least one of a plurality of clinical therapies, said information comprising, for each of said multiplicity of patients, device characteristics of said medical device, patient characteristics of each of said multiplicity of patients and an assessment of efficacy of the clinical therapies;

wherein said plurality of clinical therapies are delivered by the medical device associated with said multiplicity of patients; and

an analyzer comprising electronic equipment configured to correlate device characteristics of said prospective patient with said device characteristics, said patient characteristics and said assessment of efficacy of clinical therapies of said multiplicity of patients using said historical database to identify a prospective clinical therapy for said prospective patient associated with said device characteristics in said historical database having a relatively greater efficacy than one of plurality of said clinical therapies;

wherein said prospective clinical therapy is delivered by the medical device associated with said prospective patient;

wherein said correlating step is accomplished utilizing statistical analysis.

2. The system as in claim 1 further comprising an output configured to provide said prospective clinical therapy to a user.

3. The system as in claim 1 wherein said device characteristics comprise at least one of atrial tachycardia burden, atrial fibrillation burden, atrial tachycardia episode duration, atrial fibrillation episode duration, ventricular rate during at least one of atrial tachycardia and atrial arrhythmia, patient activity, heart rate, heart rate variability, defibrillation shocks, ventricular tachycardia, ventricular fibrillation, attempts at ventricular antitachycardia pacing, success at ventricular antitachycardia pacing, attempts at atrial antitachycardia pacing, success at atrial antitachycardia pacing, thoracic impedance, respiration, pressure, heart sounds, electrocardiogram timing, electrocardiogram morphology, proportion of atrial pacing, proportion of ventricular pacing, bradycardia episodes, asystole episodes, premature atrial contractions, premature ventricular contractions, patient inputs indicative of symptomatic episodes and patient-initiated shocks.

4. The system as in claim 1 wherein said patient characteristics comprise at least one of age, gender, body mass index, weight, blood pressure, prior hospitalizations, family history of disease, symptom status, New York Heart Association classification, medications being taken, prior cardiovascular surgeries/procedures, left ventricular ejection fraction, left atrial diameter, cardiac output, left ventricular chamber dimensions, values indicative of quality of life, functional capacity measure, CHADS2 score, congestive heart failure, diabetes, hypertension, prior stroke or transient ischemic attack, coronary artery disease, atrial tachyarrhythmia, ventricular tachyarrhythmia, bradycardia, valvular disease and myocardial infarction.

5. The system as in claim 1 wherein said statistical analysis comprises Bayesian methods.

6. The system as in claim 1 wherein said statistical analysis comprises self-organizing maps.

7. A method of identifying a prospective clinical therapy for a prospective patient having a medical device, performed by medical apparatus, comprising the steps of:

obtaining, by said medical apparatus, device characteristics from said medical device of said prospective patient;

accessing, by said medical apparatus, a historical database incorporating information relating to a multiplicity of patients, each of said multiplicity of patients having received a medical device and each of said multiplicity of patients having undergone a at least one of a plurality of clinical therapies, said information comprising, for each of said multiplicity of patients, device characteristics of said medical device associated with said multiplicity of patients, patient characteristics of each of said multiplicity of patients and an assessment of an efficacy of said plurality of clinical therapies;

wherein said plurality of clinical therapies are delivered by the medical device associated with said multiplicity of patients; and

correlating, by said medical apparatus, said device characteristics of said prospective patient with said device characteristics of the medical device associated with said multiplicity of patients, said patient characteristics and said assessment of efficacy of at least one of said plurality of clinical therapies of said multiplicity of patients; and

identifying, by said medical apparatus, using said historical database, a prospective clinical therapy for said prospective patient associated with said device characteristics and said patient characteristics in said historical database based on said correlation, wherein said prospective clinical therapy having a relatively greater efficacy than at least one of said plurality of clinical therapies;

wherein said prospective clinical therapy is delivered by the medical device associated with said prospective patient;

wherein said correlating step is accomplished utilizing statistical analysis.

8. The method as in claim 7 further comprising a step of creating said historical database incorporating information relating to a multiplicity of patients, each of said multiplicity of patients having received a medical device and each of said multiplicity of patients having undergone at least one of a plurality of clinical therapies, said information comprising, for each of said multiplicity of patients, device characteristics of said medical device, patient characteristics and an assessment of an efficacy of at least one of said plurality of clinical therapies.

9. The method as in claim 7 further comprising a step of recommending, with said medical apparatus, to a physician said prospective clinical therapy.

10. The method as in claim 7 wherein said device characteristics comprise at least one of atrial tachycardia burden, atrial fibrillation burden, atrial tachycardia episode duration, atrial fibrillation episode duration, ventricular rate during at least one of atrial tachycardia and atrial arrhythmia, patient activity, heart rate, heart rate variability, defibrillation shocks, ventricular tachycardia, ventricular fibrillation, attempts at ventricular antitachycardia pacing, success at ventricular antitachycardia pacing, attempts at atrial antitachycardia pacing, success at atrial antitachycardia pacing, thoracic impedance, respiration, pressure, heart sounds, electrocardiogram timing, electrocardiogram morphology, proportion of atrial pacing, proportion of ventricular pacing, bradycardia episodes, asystole episodes, premature atrial contractions, premature ventricular contractions, patient inputs indicative of symptomatic episodes and patient-initiated shocks.

11. The method as in claim 7 wherein said patient characteristics comprise at least one of age, gender, body mass index, weight, blood pressure, prior hospitalizations, family history of disease, symptom status, New York Heart Association classification, medications being taken, prior cardiovascular surgeries/procedures, left ventricular ejection fraction, left atrial diameter, cardiac output, left ventricular chamber dimensions, values indicative of quality of life, functional capacity measure, CHADS2 score, congestive heart failure, diabetes, hypertension, prior stroke or transient ischemic attack, coronary artery disease, atrial tachyarrhythmia, ventricular tachyarrhythmia, bradycardia, valvular disease and myocardial infarction.

12. The method as in claim 7 wherein said statistical analysis comprises Bayesian methods.

13. The method as in claim 7 wherein said statistical analysis comprises self-organizing maps.