Vascular treatment methods

• US 8,690,907 B1
• Filed: 07/29/2013
• Issued: 04/08/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Insera Therapeutics, Inc.
• Original Assignee: Insera Therapeutics, Inc.
• Inventors: Janardhan, Vallabh, Janardhan, Vikram
• Primary Examiner(s): Severson, Ryan
• Assistant Examiner(s): Miles, Jonathan W
• Application Number:
  US13/953,556
• Time in Patent Office: 253 Days
• Field of Search: 606/159, 606/191, 606/198, 606/200
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/22031 Gripping instruments, e.g. forceps, for removing or smashing calculi A61B17/221 takes precedence
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00955 thermoplastic
• CPC Class Codes: A61B 2017/12077 Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/2217 single wire changing shape to a gripping configuration
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 25/0015 Making lateral openings in a catheter tube, e.g. holes, slits, ports, piercings of guidewire ports; Methods for processing the holes, e.g. smoothing the edges
• CPC Class Codes: A61M 25/0021 characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: D04C 1/06 Braid or lace serving particular purposes
• CPC Class Codes: D04C 3/48 : Auxiliary devices
• CPC Class Codes: D10B 2509/06 : Vascular grafts; stents
• CPC Class Codes: Y10T 156/1062 : Prior to assembly
• CPC Class Codes: Y10T 83/0596 : Cutting wall of hollow work

Abstract

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measurable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Claims

1. A method of treating a thrombus in a vessel with self-expanding bulbs, the method comprising:

advancing a microwire in the vessel and through a guide catheter, wherein advancing the microwire includes crossing the thrombus with a distal end of the microwire;

advancing a microcatheter in the vessel and over the microwire, wherein advancing the microcatheter includes crossing the thrombus with a distal end of the microcatheter;

after advancing the microcatheter, removing the microwire from the vessel;

after removing the microwire, inserting a thrombectomy device in a radially compressed state into the microcatheter, the thrombectomy device including;

a distal portion including a plurality of wires woven to form a textile fabric, the distal portion comprising five to twenty said self-expanding bulbs and necks between and radially inward of the self-expanding bulbs; and

a proximal portion bonded to the distal portion, the proximal portion including a hypotube including a plurality of longitudinally-spaced kerfs including a plurality of interspersed cut patterns, wherein a pitch of the plurality of longitudinally-spaced kerfs varies longitudinally along the hypotube;

after inserting the thrombectomy device into the microcatheter, advancing the thrombectomy device in the vessel and through the microcatheter proximate to the distal end of the microcatheter, wherein advancing the thrombectomy device includes crossing the thrombus;

after advancing the thrombectomy device, maintaining a location of the proximal portion of the thrombectomy device while proximally retracting the microcatheter, wherein upon being unsheathed from the microcatheter at least some of the self-expanding bulbs of the elongate support structure of the thrombectomy device self-expand from a radially compressed state to a radially expanded state, wherein retracting the microcatheter is at least until the distal end of the microcatheter is proximal to the thrombus;

after retracting the microcatheter, torsionally rasping the thrombectomy device including removing portions of the thrombus attached to an endothelium wall, entrapping the thrombus in the radially expanded distal portion of the thrombectomy device, and collecting emboli in the radially expanded distal portion of the thrombectomy device; and

after torsionally rasping the thrombectomy device, retracting at a similar rate the microcatheter and the proximal portion of the thrombectomy device.

2. The method of claim 1, wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

3. A method of treating a thrombus in a vessel with self-expanding bulbs, the method comprising:

expanding from a radially compressed state to a radially expanded state a plurality of said self-expanding bulbs of a distal portion of a thrombectomy device, wherein retracting a microcatheter surrounding the plurality of self-expanding bulbs in the radially compressed state causes expansion of the plurality of said self-expanding bulbs to the radially expanded state;

entrapping the thrombus in at least some of the plurality of self-expanding bulbs in the radially expanded state; and

retracting the thrombectomy device from the vessel.

4. The method of claim 3, wherein the distal portion of the thrombectomy device comprises at least two of the plurality of bulbs having different outer diameters in the radially expanded state.

5. The method of claim 3, wherein the distal portion of the thrombectomy device is tapered.

6. The method of claim 3, wherein the distal portion of the thrombectomy device comprises at least two of the plurality of self-expanding bulbs having different shapes in the radially expanded state.

7. The method of claim 3, wherein the distal portion of the thrombectomy device comprises at least two of the plurality of self-expanding bulbs separated by a neck.

8. The method of claim 3, wherein the thrombectomy device comprises a proximal portion coupled to the distal portion, the proximal portion including a hypotube including a plurality of longitudinally spaced kerfs.

9. The method of claim 8, wherein the plurality of longitudinally spaced kerfs includes a plurality of interspersed cut patterns.

10. The method of claim 8, wherein a pitch of the plurality of longitudinally spaced kerfs varies longitudinally along the hypotube.

11. The method of claim 8, wherein at least some of the plurality of longitudinally spaced kerfs includes rounded edges.

12. The method of claim 3, wherein the distal portion comprises five to twenty said self-expanding bulbs.

13. The method of claim 6, wherein retracting the microcatheter is at least until a distal end of the microcatheter is proximal to the thrombus.

14. The method of claim 6, wherein retracting the thrombectomy device from the vessel comprises retracting the microcatheter at a similar rate.

15. The method of claim 3, wherein entrapping the thrombus includes torsionally rasping the thrombectomy device.

16. The method of claim 3, wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

17. A method of treating a thrombus in a vessel with self-expanding bulbs, the method comprising:

expanding from a radially compressed state to a radially expanded state a plurality of said self-expanding bulbs of a distal portion of a thrombectomy device, wherein retracting a microcatheter surrounding the plurality of self-expanding bulbs in the radially compressed state causes expansion of the plurality of said self-expanding bulbs to the radially expanded state; and

torsionally rasping the distal portion of the thrombectomy device, wherein torsionally rasping effects at least one of;

removing portions of the thrombus attached to an endothelium wall of the vessel, entrapping the thrombus in the distal portion of the thrombectomy device, and collecting emboli in the distal portion of the thrombectomy device.

18. The method of claim 17, wherein torsionally rasping the distal portion of the thrombectomy device comprises rotating a proximal portion of the thrombectomy device coupled to the distal portion of the thrombectomy device.

19. The method of claim 17, wherein the proximal portion includes a hypotube including a plurality of longitudinally-spaced kerfs.

20. The method of claim 17, wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.