Methods, reagents, devices and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies
First Claim
1. A vial package for a sample processing station comprising:
- a vial configured to receive and retain liquids therein, comprising a vial body and a resealable lid configured to fittingly and reversibly seal a top opening of the vial, anda tissue sample cassette,wherein the vial body, resealable lid or the tissue sample cassette is provided with a data logging device configured to electronically register and store data regarding a sample and conditions wherein said sample is processed, wherein said data logging device comprises;
a memory storage component configured to store said data, such that said data remains in association with the vial body, resealable lid or tissue sample cassette;
means for monitoring time (t) of a non-preset period during which said sample is processed, which time data is stored in said memory storage component; and
an on/off function adapted to activate/deactivate the data logging device, such that said monitoring takes place once the data logging device has been activated, the tissue sample cassette is connected to the resealable lid by means of an elongated memberwherein the vial package is autonomous, and is configured for removable insertion into the tissue processing station.
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Accused Products
Abstract
A process for the production of paraffin sections of biological tissue, especially for molecular pathology studies is disclosed. In the process, the tissue sample is simultaneously fixed, dehydrated and cleared in a first step, subsequently dehydrated and cleared in a second step and infiltrated with an inert specimen matrix in a third step. The specimen can then be further embedded in a casting supporting matrix according to the standard procedures followed by any local pathology or research laboratory. A kit and a processing station for automating paraffin embedding of a tissue sample suitable for histopathological and molecular analysis is also described. A bio-indicator system is described for measuring the degree of crosslinking. A tissue sample holding means or a vial which includes a tissue sample holding means provided with a data logging device capable of registering and transmitting data regarding the sample and conditions where the sample was processed is also disclosed.
31 Citations
22 Claims
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1. A vial package for a sample processing station comprising:
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a vial configured to receive and retain liquids therein, comprising a vial body and a resealable lid configured to fittingly and reversibly seal a top opening of the vial, and a tissue sample cassette, wherein the vial body, resealable lid or the tissue sample cassette is provided with a data logging device configured to electronically register and store data regarding a sample and conditions wherein said sample is processed, wherein said data logging device comprises; a memory storage component configured to store said data, such that said data remains in association with the vial body, resealable lid or tissue sample cassette; means for monitoring time (t) of a non-preset period during which said sample is processed, which time data is stored in said memory storage component; and an on/off function adapted to activate/deactivate the data logging device, such that said monitoring takes place once the data logging device has been activated, the tissue sample cassette is connected to the resealable lid by means of an elongated member wherein the vial package is autonomous, and is configured for removable insertion into the tissue processing station. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification