Anti-Aβ globulomer 5F7 antibodies
First Claim
1. An antibody selected from the group consisting of an isolated antibody, a monoclonal antibody and a recombinant antibody, wherein said antibody has a binding affinity to an Aβ
- (20-42) globulomer that is greater than the binding affinity of the antibody to an Aβ
(1-42) globulomer;
wherein the binding affinity of the antibody to the Aβ
(20-42) globulomer is at least 10 times greater than the binding affinity of the antibody to the Aβ
(1-42) globulomer, whereinthe antibody is humanized and binds to the same epitope as a monoclonal antibody 5F7 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7241.
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Accused Products
Abstract
Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.
The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer'"'"'s disease and other amyloidoses.
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Citations
16 Claims
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1. An antibody selected from the group consisting of an isolated antibody, a monoclonal antibody and a recombinant antibody, wherein said antibody has a binding affinity to an Aβ
- (20-42) globulomer that is greater than the binding affinity of the antibody to an Aβ
(1-42) globulomer;
wherein the binding affinity of the antibody to the Aβ
(20-42) globulomer is at least 10 times greater than the binding affinity of the antibody to the Aβ
(1-42) globulomer, whereinthe antibody is humanized and binds to the same epitope as a monoclonal antibody 5F7 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7241. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- (20-42) globulomer that is greater than the binding affinity of the antibody to an Aβ
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8. An antibody selected from the group consisting of an isolated antibody, a monoclonal antibody and a recombinant antibody, wherein said antibody comprises two variable domains, wherein said two variable domains are SEQ ID NO:
- 3 and SEQ ID NO;
4. - View Dependent Claims (9, 10, 11, 12, 13, 14)
- 3 and SEQ ID NO;
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15. Monoclonal antibody (5F7) obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7241.
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16. Hybridoma designated by an American Type Culture Collection deposit number PTA-7241.
Specification