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Anti-Aβ globulomer 5F7 antibodies

  • US 8,691,224 B2
  • Filed: 11/30/2006
  • Issued: 04/08/2014
  • Est. Priority Date: 11/30/2005
  • Status: Active Grant
First Claim
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1. An antibody selected from the group consisting of an isolated antibody, a monoclonal antibody and a recombinant antibody, wherein said antibody has a binding affinity to an Aβ

  • (20-42) globulomer that is greater than the binding affinity of the antibody to an Aβ

    (1-42) globulomer;

    wherein the binding affinity of the antibody to the Aβ

    (20-42) globulomer is at least 10 times greater than the binding affinity of the antibody to the Aβ

    (1-42) globulomer, whereinthe antibody is humanized and binds to the same epitope as a monoclonal antibody 5F7 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7241.

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