Implantable or insertable medical devices for controlled drug delivery
First Claim
1. An implantable or insertable medical device comprising:
- (a) an extruded first biocompatible matrix polymer region that comprises a matrix polymer and at least one therapeutic agent and (b) a coextruded second biocompatible matrix polymer region that comprises a matrix polymer and at least one therapeutic agent, wherein one of the matrix polymers comprises a non-biodegradable polymer and another of the matrix polymers comprises a biodegradable polymer.
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Accused Products
Abstract
Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
147 Citations
22 Claims
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1. An implantable or insertable medical device comprising:
- (a) an extruded first biocompatible matrix polymer region that comprises a matrix polymer and at least one therapeutic agent and (b) a coextruded second biocompatible matrix polymer region that comprises a matrix polymer and at least one therapeutic agent, wherein one of the matrix polymers comprises a non-biodegradable polymer and another of the matrix polymers comprises a biodegradable polymer.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An implantable or insertable medical device comprising:
- (a) a first extruded polymeric matrix region comprising a first biocompatible polymer and a therapeutic agent, and (b) a second extruded polymer matrix region comprising a second biocompatible polymer and a radio-opacifying agent, wherein said first and second biocompatible polymers may be the same or different.
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22. An implantable or insertable medical device comprising:
- a single-layer matrix polymer structure formed from a mixture comprising an extruded polymeric matrix region comprising (a) a biocompatible polymer, (b) a radio-opacifying agent, and (c) at least one therapeutic agent, wherein said medical device is adapted for implantation or insertion at a site that is associated with pain or discomfort upon implantation or insertion.
Specification