Transdermal delivery using encapsulated agent released by ultrasound and/or heat
First Claim
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1. A portable transdermal drug delivery device consisting of:
- (A) a transdermal patch for infusing active substances into a user'"'"'s body through the skin comprising;
an inner disc, the inner disc including (i) encapsulated agents in microcapsules, wherein the microcapsules retain the encapsulated agents prior to activation by energy capable of rupturing the microcapsules and (ii) an external matrix or vehicle; and
an outer disc for attachment of the patch to the skin of the user, thereby facilitating contact of the inner disc with a surface of the skin;
(B) an activating probe attached to said transdermal patch and being equipped with a single multi-source element,wherein said multi-source element is comprised of multiple energy sources for providing ultrasound radiation or heat energy at different localized areas of said inner disc,wherein said activating probe is adapted for activating the transdermal patch by rupturing the microcapsules, thereby releasing said encapsulated agents into the external matrix or vehicle of the inner disc of said transdermal patch; and
(C) a power supply for supplying energy to said multi-source element.
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Abstract
A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
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Citations
15 Claims
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1. A portable transdermal drug delivery device consisting of:
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(A) a transdermal patch for infusing active substances into a user'"'"'s body through the skin comprising; an inner disc, the inner disc including (i) encapsulated agents in microcapsules, wherein the microcapsules retain the encapsulated agents prior to activation by energy capable of rupturing the microcapsules and (ii) an external matrix or vehicle; and
an outer disc for attachment of the patch to the skin of the user, thereby facilitating contact of the inner disc with a surface of the skin;(B) an activating probe attached to said transdermal patch and being equipped with a single multi-source element, wherein said multi-source element is comprised of multiple energy sources for providing ultrasound radiation or heat energy at different localized areas of said inner disc, wherein said activating probe is adapted for activating the transdermal patch by rupturing the microcapsules, thereby releasing said encapsulated agents into the external matrix or vehicle of the inner disc of said transdermal patch; and (C) a power supply for supplying energy to said multi-source element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification