Controlled degradation of expandable polymers in gastric volume reduction treatment

• US 8,691,269 B2
• Filed: 11/04/2005
• Issued: 04/08/2014
• Est. Priority Date: 11/05/2004
• Status: Active Grant

• Current Assignee: Eatlittle Incorporated
• Original Assignee: Eatlittle Incorporated
• Inventors: Mintchev, Martin Pavlov, Yadid-Pecht, Orly
• Primary Examiner(s): ZISKA, SUZANNE E
• Application Number:
  US11/718,514
• Publication Number:
  US 20090035367A1
• Time in Patent Office: 3,077 Days
• Field of Search: None
• US Class Current: 424/452
• CPC Class Codes: A61F 5/0036 Intragastrical devices
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

Orally administrable polymer-carrying units for expanding in a stomach of a mammal to fill a space in the stomach, the polymer-carrying units including: a carrier; a plurality of polymer molecules expandable in aqueous solutions, releasably coupled to the carrier; and means for selectively decoupling the polymer molecules from the carrier so that the polymer molecules and carrier are released in the stomach, are provided.

Claims

1. An orally administrable polymer-carrying unit for expanding in a stomach of a mammal to fill a space in the stomach, the polymer-carrying unit comprising:

(a) a carrier having an outer surface and an inner surface, the inner surface forming an internal cavity;

(b) at least one fiber for releasably attaching at least one permeable sac to the carrier, the at least one fiber being threaded into or through the internal cavity of the carrier so that at least one segment of the at least one fiber is located within the internal cavity, the at least one permeable sac containing therein at least one polymer molecule that is expandable in the presence of an aqueous solution, the permeable sac allowing liquid contained in the stomach to enter the sac and expand the at least one polymer molecule so that the unit is retained in the stomach; and

(c) a decoupler located in the internal cavity for non-invasively decoupling the at least one permeable sac from the carrier by cutting the internal segment of the at least one fiber so that the at least one permeable sac is released into the stomach and can now exits the stomach through normal peristaltic movement.

2. The polymer-carrying unit of claim 1, wherein the decoupler comprises an electrical wire operably associated with the carrier, the electrical wire being heated when it is desirable to melt and cut through the internal segment of the fiber.

3. The polymer-carrying unit of claim 1, wherein the at least one polymer molecule is a mixture of Bentonite and a biocompatible polymer.

4. The polymer-carrying unit of claim 1, wherein the at least one polymer molecule is biodegradable.

5. The polymer-carrying unit of claim 1, wherein the unit is encapsulated in a shell.

6. The polymer-carrying unit of claim 1, wherein the at least one polymer molecule is a biocompatible polymer.

7. The polymer-carrying unit of claim 1, wherein the at least one polymer molecule is selected from the group consisting of natural clays, microcrystalline hydrogels, polyolefins, polyvinyl alcohol, poly(ethyloxazoline), polyvinylacetate-polyvinylalcohol copolymers, poly(2-hydroxyethylacrylate), poly(2-hydroxyethylmethacrylate), polyacrylic acid, and copolymers thereof, polysaccharides, water soluble proteins, polynucleic acids, or a combination thereof.

8. The polymer-carrying unit of claim 1, wherein the at least one permeable sac comprises an expandable permeable liner.

9. The polymer-carrying unit of claim 1, wherein the at least one permeable sac comprises a natural cellulose fiber, a specialty fiber made through spun laced process, a spun-bonded polypropylene or absorbable haemostatic oxidised regenerated cellulose.

10. The polymer-carrying unit of claim 1, wherein the at least one permeable sac comprises a biodegradable material thereby releasing the at least one polymer and the at least one permeable sac and the at least one polymer exit the stomach through normal peristaltic movement.

11. The polymer-carrying unit of claim 5, wherein the shell is made of gelatin or cellulose.