Gallium-containing sealant for medical use

• US 8,691,288 B2
• Filed: 07/13/2011
• Issued: 04/08/2014
• Est. Priority Date: 05/10/2006
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Myntti, Matthew F.
• Primary Examiner(s): ZISKA, SUZANNE E
• Application Number:
  US13/182,275
• Publication Number:
  US 20110300235A1
• Time in Patent Office: 1,000 Days
• Field of Search: None
• US Class Current: 424/650
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.

Claims

1. A polymeric medical sealant article of manufacture, the medical sealant article comprising a protective layer that contacts a deciliated mucosal tissue portion from which a biofilm has been removed, and the protective layer comprising sufficient polymeric film-former and sufficient gallium-containing antimicrobial agent to reduce biofilm reformation on such tissue portion.

2. A medical sealant article according to claim 1, wherein the film-former comprises a synthetic polymer, natural polymer or synthetically-modified natural polymer.

3. A medical sealant article according to claim 1, wherein the film-former comprises polyethylene glycol.

4. A medical sealant article according to claim 1, wherein the film-former comprises a polysaccharide, lipid or polypeptide.

5. A medical sealant article according to claim 1 wherein the film-former comprises carboxymethyl cellulose.

6. A medical sealant article according to claim 1, wherein the film-former comprises a chitin.

7. A medical sealant article according to claim 1 wherein the film-former comprises hyaluronan.

8. A medical sealant article according to claim 1, wherein the film-former comprises a collagen.

9. A medical sealant article according to claim 1, wherein the film-former comprises a polypeptide reacted with an aldehyde.

10. A medical sealant article according to claim 1, wherein the gallium-containing antimicrobial agent comprises gallium acetoacetonate, gallium bromide, gallium chloride, gallium fluoride, gallium iodide, gallium maltolate, gallium nitrate, gallium nitride, gallium percolate, gallium phosphite, gallium sulfate or mixture thereof.

11. A medical sealant article according to claim 1, wherein the gallium-containing antimicrobial agent comprises gallium nitrate.

12. A medical sealant article according to claim 1, wherein the protective layer is uncrosslinked.

13. A medical sealant article according to claim 1, wherein the protective layer is crosslinked.

14. A medical sealant article according to claim 1, wherein the protective layer contacts a deciliated nasal or sinus mucosal tissue portion.