FAIMS having a displaceable electrode for on/off operation
First Claim
1. A system for analyzing ions, comprising:
- an ion source for generating ions;
a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell comprising;
(a) a gas inlet;
(b) an outer electrode having a generally concave inner surface and comprising;
(i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and
(ii) an ion outlet; and
(c) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode so as to define at least one annular ion separation region therebetween; and
a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet,wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the at least one annular ion separation region, the second position facilitating movement of the ions through the conduit.
1 Assignment
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Accused Products
Abstract
A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode defining at least one annular on separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first and second positions facilitating movement of the ions through the at least one annular ion separation region and the conduit, respectively.
48 Citations
11 Claims
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1. A system for analyzing ions, comprising:
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an ion source for generating ions; a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell comprising; (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising; (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode so as to define at least one annular ion separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the at least one annular ion separation region, the second position facilitating movement of the ions through the conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for analyzing ions, comprising:
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an ionization chamber; an atmospheric pressure ion source within the ionization chamber for generating ions; a first reduced pressure chamber; an ion transfer tube having a first end disposed within the ionization chamber for receiving ions from the ion source and a second end disposed within the first reduced pressure chamber; a heater in thermal contact with the ion transfer tube applying heat to the ion transfer tube; a carrier gas conduit for introducing a flow of carrier gas into the ion transfer tube; a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell within the first reduced pressure chamber comprising; (a) an outer electrode having a generally concave inner surface and comprising; (i) an ion inlet operable to receive the ions and the carrier gas from the second end of the ion transfer tube; and (ii) an ion outlet; and (b) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode so as to define at least one annular ion separation region therebetween, the inner electrode being moveable between a first position and a second position, the first position facilitating movement of the ions through the at least one annular ion separation region, the second position facilitating movement of the ions through the conduit; a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet; and a housing of the mass analyzer comprising at least one evacuated chamber fluidically coupled to the ion outlet of the FAIMS cell.
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10. A system for analyzing ions, comprising:
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an ion source for generating ions; a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell comprising; (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising; (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode so as to define at least one annular ion separation region therebetween, the inner electrode being moveable between a first position and a second position, the first position facilitating movement of the ions through the at least one annular ion separation region, the second position facilitating movement of the ions through the conduit; a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, the mass analyzer separated from the FAIMS cell by a gap therebetween; a gas-tight coupling between the FAIMS cell and the mass analyzer within the gap; and at least one vacuum port coupled to the mass analyzer for maintaining the mass analyzer and the FAIMS ion separation region at sub-atmospheric pressure. - View Dependent Claims (11)
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Specification