Apparatus and method for estimating stroke volume of the heart using bio-impedance techniques

• US 8,694,089 B2
• Filed: 02/13/2012
• Issued: 04/08/2014
• Est. Priority Date: 07/03/2002
• Status: Active Grant

• Current Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Original Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Inventors: Arad (Abboud), Shimon
• Primary Examiner(s): DOUGHERTY, SEAN PATRICK
• Application Number:
  US13/371,592
• Publication Number:
  US 20120150050A1
• Time in Patent Office: 785 Days
• Field of Search: 600/300, 600/301, 600/425, 600/547, 600/428, 600/509, 600/513, 600/526
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/7289 Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal

Abstract

A method of estimating stroke volume of the heart is described. In this method, the volume of the heart is estimated from electrical impedance data of the chest, at two different phases of the cardiac cycle. The stroke volume is estimated from the difference between the volumes estimated at the two phases.

Claims

1. A method for measuring fluid in a subject'"'"'s lungs, comprising:

a) placing at least four electrodes around a subject'"'"'s chest;

b) obtaining one or more sets of impedance data, each set consisting of a voltage measured between a first pair of the electrodes while passing current through the subject'"'"'s chest through a second pair of the electrodes, both the electrodes in the second pair not belonging to the first pair; and

c) estimating a degree of fluid in the subject'"'"'s lungs, using one or more of the sets of impedance data obtained from a total of eight or fewer of the electrodes.

2. A method according to claim 1, wherein, for at least first one of the sets of impedance data, one of the pairs of electrodes is placed respectively on the front right side and back left side of the subject'"'"'s chest, and the other one of the pairs of electrodes is placed respectively on the front left side and back right side of the subject'"'"'s chest.

3. A method according to claim 2, wherein at least a second set of impedance data is obtained, for which the voltage is measured between the pair of electrodes through which the current is passed for the first set, while the current is passed through the pair of electrodes between which the voltage is measured for the first set.

4. A method according to claim 2, wherein the pairs of electrodes for the first one of the sets of impedance data are placed closer to the sides of the subject'"'"'s body than to a midplane of the subject'"'"'s body.

5. A method according to claim 1, wherein estimating the degree of fluid in the subject'"'"'s lungs comprises solving an inverse problem to find a specific impedance of the subject'"'"'s lungs, according to an image or model of the chest.

6. A method according to claim 1, also comprising obtaining electrocardiograph data of the subject, wherein estimating the degree of fluid in the subject'"'"'s lungs comprises:

reconstructing a plurality of preliminary impedance images of the chest from the electrical data;

using the electrocardiograph data to determine a phase of breathing cycle of the subject, a cardiac cycle of the subject, or both, for each of the preliminary images;

sorting the preliminary images into a plurality of bins according to the cardiac cycle, the breathing cycle, or both; and

using the sorted preliminary impedance images to obtain a corrected impedance image of the subject'"'"'s chest.

7. A method according to claim 5, wherein the image or model of the chest is used to make an initial guess for an impedance distribution of the chest, for solving the inverse problem.

8. A method according to claim 5, wherein the image or model of the chest is used to make a grid, used for solving the inverse problem, conform to a surface of the lungs, a surface of the heart, or both.

9. A method according to claim 5, wherein solving the inverse problem comprises using a finite volume method and calculating a Jacobian analytically.

10. A method according to claim 1, wherein placing the electrodes around the chest comprises placing all the electrodes substantially at a same level around the chest.

11. A method according to claim 1, wherein the current is between 1 and 5 milliamps.

12. A method according to claim 1, wherein the current is an alternating current at a frequency between 10 kHz and several hundred kHz.

13. A method according to claim 1, wherein placing the electrodes around the chest comprises placing around the chest a belt that the electrodes are mounted on, the belt being placed tightly enough to hold the electrodes against the chest.

14. A method according to claim 13, also comprising using at least some of the electrodes mounted on the belt to obtain electrocardiograph data of the subject, while obtaining the one or more sets of impedance data.

15. A method according to claim 1, wherein the total of eight or fewer of the electrodes consists of exactly four electrodes.

16. A method according to claim 1, wherein the total of eight or fewer of the electrodes consists of exactly five electrodes.

17. A method according to claim 1, wherein the total of eight or fewer of the electrodes consists of exactly six electrodes.

18. A method according to claim 1, wherein the total of eight or fewer of the electrodes consists of exactly seven electrodes.

19. A method according to claim 1, wherein the total of eight or fewer of the electrodes consists of exactly eight electrodes.

20. A method according to claim 1, wherein each of the one or more sets of impedance data is obtained while passing current through only one pair of the electrodes.

21. A system for measuring fluid in a subject'"'"'s lungs, comprising:

a) at least four electrodes adapted for placing around a human subject'"'"'s chest;

b) a power supply capable of passing a known current through the subject'"'"'s chest through a first pair of the electrodes, when they are placed on the subject'"'"'s chest;

c) a voltage measuring instrument capable of measuring a voltage between a second pair of the electrodes, distinct from the first pair, when the power supply is passing the known current through the subject'"'"'s chest through the first pair of electrodes, and when the first and second pair of electrodes are placed on the subject'"'"'s chest; and

d) a controller which estimates a degree of fluid in the subject'"'"'s lungs, using one or more voltages measured between pairs of the electrodes for known currents passed through other pairs of the electrodes, for electrodes placed at no more than eight locations around the chest.

22. A system according to claim 21, wherein the controller is configured to estimate the degree of fluid in the subject'"'"'s lungs by solving an inverse problem to find a specific impedance of the subject'"'"'s lungs, according to an image or model of the chest.

23. A system according to claim 21, comprising a belt that the electrodes are mounted to, which holds the electrodes in place against the chest when it is placed around the chest.

24. A system according to claim 21, comprising an electrocardiograph, wherein the controller is configured to reconstruct a preliminary impedance image of the chest using the voltages measured for the known currents, to reconstruct a corrected impedance image from the preliminary impedance image using data of the subject from the electrocardiograph to correct for the subject'"'"'s cardiac cycle, breathing cycle, or both, and to estimate the degree of fluid in the subject'"'"'s lungs from the corrected impedance image.

25. A system according to claim 21, wherein the power supply comprises an AC power supply capable of passing at least 1 milliamp of current at a frequency of at least 10 kHz.