Neurostimulation system having a controller for controlling the supply of electrical pulses

• US 8,694,105 B2
• Filed: 07/03/2008
• Issued: 04/08/2014
• Est. Priority Date: 07/10/2007
• Status: Active Grant

• Current Assignee: Medtronic Bakken Research Center B.V. (Medtronic Plc)
• Original Assignee: Sapiens Steering Brain Stimulation B.V. (Medtronic Plc)
• Inventors: Martens, Hubert Cecile Francois, Decre, Michel Marcel Jose, Cantatore, Eugenio
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US12/667,399
• Publication Number:
  US 20100198315A1
• Time in Patent Office: 2,105 Days
• Field of Search: 600/378, 607/45, 607/57
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

The invention relates to a neurostimulation system, particularly for deep brain stimulation (DBS), comprising a spatial array (130) of stimulation electrodes (132) and an associated controller (110). The controller (110) is adapted to sequentially supply electrical pulses to different subsets of the stimulation electrodes (132). Preferably, the controller (110) comprises a single pulse-generator (112) and a multiplexing unit (111) for distributing the pulses to different stimulation electrodes. The stimulation electrodes (132) may preferably be arranged on probes (131).

Claims

1. A method for controlling a plurality of stimulation electrodes of a neurostimulation system that are arranged in an array, the method comprising:

a) implanting the plurality of stimulation electrodes into brain tissue;

b) generating a sequence of electrical pulses using at least one pulse generator; and

c) sequentially distributing each pulse of the sequence of electrical pulses one at a time to different subsets of stimulation electrodes,

wherein each subset of stimulation electrodes includes a plurality of the plurality of stimulation electrodes.

2. The method according to claim 1, wherein a frequency in which a subset receives a pulse is equal to a frequency the electrical pulses are generated divided by the number of subsets.

3. The method according to claim 1, wherein the frequencies in which the subsets receive the sequence of electrical pulses are out of phase with one another.

4. The method according to claim 1 further comprising:

implanting the plurality of stimulation electrodes into brain tissue.

5. The method according to claim 1, wherein the pulses are distributed sequentially to different subsets of stimulation electrodes using a multiplexing unit.

6. The method according to claim 1, wherein an activation volume of each subset of the stimulation electrodes at least partially overlaps at least one other activation volume of another subset of the stimulation electrodes.

7. The method according to claim 1, wherein the stimulation electrodes include a plurality of probes, each probe including a subset of stimulation electrodes.

8. The method according to claim 1, wherein the sequence of electrical pulses are generated by a single pulse generator.

9. The method according to claim 1, wherein the distribution of each pulse from the sequence of electrical pulses is configured to yield an increased volume of stimulated neural tissue.

10. A method for controlling a plurality of stimulation electrodes of a neurostimulation system that are arranged in an array, the stimulation electrodes including a plurality of probes, each probe including a subset of stimulation electrodes, the method comprising:

implanting the plurality of probes into brain tissue;

generating a sequence of electrical pulses using an implantable pulse generator; and

sequentially distributing each pulse of the sequence of electrical pulses one at a time to different subsets of stimulation electrodes using a multiplexing unit,

wherein each subset of stimulation electrodes includes a plurality of the plurality of stimulation electrodes.