Method and apparatus for increasing blood flow through an obstructed blood vessel

• US 8,696,622 B2
• Filed: 11/08/2012
• Issued: 04/15/2014
• Est. Priority Date: 02/01/2006
• Status: Active Grant

• Current Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Original Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Inventors: Fiorella, David, Woo, Henry
• Primary Examiner(s): SHUMATE, VICTORIA PEARL
• Application Number:
  US13/672,445
• Publication Number:
  US 20130165871A1
• Time in Patent Office: 523 Days
• Field of Search: 604/96.01, 604/97.01, 604/99.01, 60410301-10303, 604/103.05, 604/103.06, 604/103.08, 604/103.09
• US Class Current: 604/103.08
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22061 for spreading elements apart
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2017/320004 abrasive
• CPC Class Codes: A61B 2017/320008 Scrapers
• CPC Class Codes: A61B 2017/320733 with a flexible cutting or scraping element, e.g. with a whip-like distal filament member
• CPC Class Codes: A61B 2017/320741 for stripping the intima or the internal plaque from a blood vessel, e.g. for endarterectomy
• CPC Class Codes: A61M 2025/1088 having special surface characteristics depending on material properties or added substances, e.g. for reducing friction
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1027 Making of balloon catheters
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member.

Claims

1. An expandable member and a delivery system for removing an obstruction from a blood vessel, comprising:

a delivery system; and

an expandable member comprising;

a proximal member end permanently attached to the delivery system;

a distal member end;

a member body extending between the proximal and distal member ends and, the member body expandable from a first diameter to a second diameter, the second diameter being larger than the first diameter, such that when the member body is expanded to the second diameter, the member body contacts at least a portion of the obstruction within a blood vessel to enhance blood flow through the blood vessel; and

said member body further comprising at least a portion of the member body made of a first mesh having a plurality of first interstices, at least one of the first interstices being adapted to allow passage of at least one dislodged portion of the obstruction therethrough in a radial direction into the member body.

2. The expandable member and the delivery system of claim 1, wherein the obstruction is dislodged by fracturing a portion of the obstruction.

3. The expandable member and the delivery system of claim 1, wherein the obstruction is dislodged by extruding a portion of the obstruction.

4. The expandable member and the delivery system of claim 1, wherein the expandable member includes at least one radiopaque portion.

5. The expandable member and the delivery system of claim 1, said expandable member being at least partially constructed of a self-expanding material.

6. The expandable member and the delivery system of claim 1, wherein the blood vessel is a cerebral blood vessel.

7. The expandable member and the delivery system of claim 1, said expandable member being at least partially adapted to elute a pharmaceutical agent.

8. The expandable member and the delivery system of claim 7, wherein the pharmaceutical agent is adapted to at least partially lyse at least one fragment of the at least one dislodged portion of the obstruction.

9. The expandable member and the delivery system of claim 1, wherein the proximal member end of the expandable member is closed and is made of a second mesh having a plurality of second interstices, at least one of the second interstices being adapted to selectively allow passage of at least one fragment therethrough.

10. The expandable member and the delivery system of claim 9, wherein said first mesh is formed integrally with the second mesh.

11. The expandable member and the delivery system of claim 9, wherein at least one of the plurality of second interstices is smaller than at least one of the plurality of first interstices.

12. The expandable member and the delivery system of claim 9, wherein the size of at least one of the plurality of second interstices is chosen depending upon an allowable particulate size of the blood vessel.

13. The expandable member and the delivery system of claim 1, wherein at least one of the first interstices is defined by a plurality of first strands, and at least one of the plurality of first strands is adapted to penetrate into the obstruction to longitudinally separate at least one fragment of the at least one dislodged portion of the obstruction from a remaining portion of the obstruction.

14. The expandable member and the delivery system of claim 1, wherein the proximal member end of the expandable member is closed and is made of a second mesh having a plurality of second interstices, said first mesh is formed integrally with the second mesh, and at least one of the second interstices is defined by a plurality of second strands, at least one of the plurality of second strands is adapted to break at least one fragment of the at least one dislodged portion of the obstruction into a plurality of subfragments, and at least one of the second interstices is adapted to selectively allow passage therethrough of at least one subfragment to release the at least one subfragment from the expandable member.

15. The expandable member and the delivery system of claim 1, wherein the member body is adapted to compress at least a portion of the obstruction against a vessel wall of the blood vessel.

16. The expandable member and the delivery system of claim 1, wherein the member body defines a body interior, the expandable member including a guidewire extending longitudinally between the distal and proximal member ends through the body interior, the guidewire being attached to a closed one of the distal and proximal member ends.

17. The expandable member and the delivery system of claim 16, wherein the guidewire extends beyond at least one of the distal and proximal member ends and is adapted to permanently attach the expandable member to the delivery system.

18. The expandable member and the delivery system of claim 1, wherein the expandable member includes a plurality of strands forming the first mesh and a second mesh and wherein each of the strands is oriented in at least one of a helical, longitudinal, and radial direction with respect to the member body.

19. The expandable member and the delivery system of claim 1, wherein said distal member end of the expandable member is open.

20. The expandable member and the delivery system of claim 1, wherein the member body of the expandable member is tubular in shape.