Coating composition
First Claim
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1. An implantable medical device capable of delivering medicinal agents, the implantable medical device comprising:
- a plurality of wound care beads, wherein the wound care beads comprisea first layer on a surface of the wound care beads, said first layer having an outside surface and containing a bioactive agent and a polymeric material, wherein the polymeric material with a backbone including at least one selected from the group consisting of poly(vinylpyrrolidone), polyethylene oxide, and polyethylene glycol, is crosslinked to the surface of the implantable medical device; and
a second layer on the outside surface of said first layer, said second layer comprising poly(butylmethacrylate)poly(ethylene-co-vinyl acetate) and a photoreagent,wherein the second layer is crosslinked to the outside surface of the first layer,wherein the surface of the wound care beads comprises a hydrophilic polymeric surface.
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Abstract
A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
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Citations
6 Claims
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1. An implantable medical device capable of delivering medicinal agents, the implantable medical device comprising:
a plurality of wound care beads, wherein the wound care beads comprise a first layer on a surface of the wound care beads, said first layer having an outside surface and containing a bioactive agent and a polymeric material, wherein the polymeric material with a backbone including at least one selected from the group consisting of poly(vinylpyrrolidone), polyethylene oxide, and polyethylene glycol, is crosslinked to the surface of the implantable medical device; and a second layer on the outside surface of said first layer, said second layer comprising poly(butylmethacrylate)poly(ethylene-co-vinyl acetate) and a photoreagent, wherein the second layer is crosslinked to the outside surface of the first layer, wherein the surface of the wound care beads comprises a hydrophilic polymeric surface. - View Dependent Claims (2, 3, 4, 5, 6)
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