Coating composition

• US 8,697,106 B2
• Filed: 09/23/2011
• Issued: 04/15/2014
• Est. Priority Date: 07/07/2006
• Status: Active Grant

• Current Assignee: Surmodics Incorporated
• Original Assignee: Surmodics Incorporated
• Inventors: Kloke, Tim M., Keough, Steven J., Lockwood, Nathan, Gardner, Margaret R., Hergenrother, Robert W., Chappa, Ralph A.
• Primary Examiner(s): Schnizer, Richard
• Assistant Examiner(s): Zhang, Yanzhi
• Application Number:
  US13/242,837
• Publication Number:
  US 20120021038A1
• Time in Patent Office: 935 Days
• Field of Search: 424/422, 424/423, 604/304
• US Class Current: 424/422
• CPC Class Codes: A61L 17/005 containing a biologically active substance, e.g. a medicament or a biocide
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/62 Encapsulated active agents, e.g. emulsified droplets
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.

Claims

1. An implantable medical device capable of delivering medicinal agents, the implantable medical device comprising:

a plurality of wound care beads, wherein the wound care beads comprise

a first layer on a surface of the wound care beads, said first layer having an outside surface and containing a bioactive agent and a polymeric material, wherein the polymeric material with a backbone including at least one selected from the group consisting of poly(vinylpyrrolidone), polyethylene oxide, and polyethylene glycol, is crosslinked to the surface of the implantable medical device; and

a second layer on the outside surface of said first layer, said second layer comprising poly(butylmethacrylate)poly(ethylene-co-vinyl acetate) and a photoreagent,

wherein the second layer is crosslinked to the outside surface of the first layer,

wherein the surface of the wound care beads comprises a hydrophilic polymeric surface.

2. The implantable medical device of claim 1, further comprising a third layer outside the first layer, the third layer comprising poly(butylmethacrylate).

3. The implantable medical device of claim 1, wherein the second layer further comprises poly(vinylpyrrolidone).

4. The implantable medical device of claim 1, wherein the bioactive agent is selected from tobramycin, tobramycin sulfate, vancomycin, amikacin, gentamicin, kanamycin, neomycin, tigecycline, netilmicin, paromomycin, streptomycin, and apramycin and combinations thereof.

5. The implantable medical device of claim 1, wherein the poly(ethylene-co-vinyl acetate) comprises poly(ethylene-co-vinyl acetate) polymers having vinyl acetate concentrations of between about 10% and about 50% by weight.

6. The implantable medical device of claim 2, wherein the bioactive agent has an elution profile such that at least 50 percent of the bioactive agent releases from the first, second, and third layers within 72 hours of placement within a wound.