Method for making a porous polymeric material
First Claim
1. A process for making a porous polymeric material, comprising the steps of:
- (a) providing a polymer consisting essentially of polyurethane comprising a siloxane moiety or a carbonate moiety;
(b) identifying a liquid swelling agent that does not dissolve the polymer in solid form, but instead merely swells the solid polymer, said liquid swelling agent being selected from the group consisting of p-dioxane and dimethyl sulfoxide;
(c) providing at least sufficient tetrahydrofuran to said polymer as to dissolve the polymer in the tetrahydrofuran to form a solution;
(d) adding a quantity of the liquid swelling agent to the solution, whereupon the entire volume of solution begins to increase its viscosity without forming a separation of solid and liquid phases;
(e) continuing to add the liquid swelling agent to the solution until the entire volume of solution transforms to gel, the gelation being without visible separation of a solid phase and a liquid phase;
(f) shape-forming the gel; and
(g) removing the tetrahydrofuran and liquid swelling agent from the gel.
2 Assignments
0 Petitions
Accused Products
Abstract
Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may incorporate biologically active agents, and which agents may be delivered in a time-staged delivery manner, where differing drugs may be delivered over differing periods.
59 Citations
6 Claims
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1. A process for making a porous polymeric material, comprising the steps of:
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(a) providing a polymer consisting essentially of polyurethane comprising a siloxane moiety or a carbonate moiety; (b) identifying a liquid swelling agent that does not dissolve the polymer in solid form, but instead merely swells the solid polymer, said liquid swelling agent being selected from the group consisting of p-dioxane and dimethyl sulfoxide; (c) providing at least sufficient tetrahydrofuran to said polymer as to dissolve the polymer in the tetrahydrofuran to form a solution; (d) adding a quantity of the liquid swelling agent to the solution, whereupon the entire volume of solution begins to increase its viscosity without forming a separation of solid and liquid phases; (e) continuing to add the liquid swelling agent to the solution until the entire volume of solution transforms to gel, the gelation being without visible separation of a solid phase and a liquid phase; (f) shape-forming the gel; and
(g) removing the tetrahydrofuran and liquid swelling agent from the gel. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification