Composition for preserving platelets and method of using the same
First Claim
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1. A platelet preservation composition, comprising:
- a) an antiplatelet agent;
b) an anticoagulant; and
c) a pharmaceutically acceptable oxygen carrier;
wherein said antiplatelet agent comprises a short-to-ultrashort acting GPIIb/IIIA inhibitor that is not a cyclic-RGD peptide, wherein said anticoagulant comprises a short-to-ultrashort acting factor IIa inhibitor, and wherein said composition is capable of extending the shelf-life of platelets in a platelet preparation.
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Abstract
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
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Citations
18 Claims
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1. A platelet preservation composition, comprising:
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a) an antiplatelet agent; b) an anticoagulant; and c) a pharmaceutically acceptable oxygen carrier; wherein said antiplatelet agent comprises a short-to-ultrashort acting GPIIb/IIIA inhibitor that is not a cyclic-RGD peptide, wherein said anticoagulant comprises a short-to-ultrashort acting factor IIa inhibitor, and wherein said composition is capable of extending the shelf-life of platelets in a platelet preparation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of extending the shelf-life of platelets, comprising the steps of:
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(a) admixing a preservative composition with unactivated, functional platelets to provide a preserved platelet composition; and (b) store the preserved platelet composition in an oxygen-permeable container or an oxygen-impermeable container, wherein the preservative composition comprises an antiplatelet agent, an anticoagulant, and a pharmaceutically acceptable oxygen carrier, wherein said antiplatelet agent comprises a short-to-ultrashort acting GPIIb/IIIA inhibitor that is not a cyclic-RGD peptide and wherein said anticoagulant comprises a short-to-ultrashort acting factor IIa inhibitor. - View Dependent Claims (16, 17, 18)
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Specification