Modular point-of-care devices, systems, and uses thereof
First Claim
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1. A method for transferring a reagent to an assay unit, comprising:
- A) inserting a cartridge into an instrument, wherein the cartridge comprises i) an identifier, ii) an assay unit configured to run a chemical reaction that yields a signal indicative of an analyte, and iii) a reagent unit comprising a reagent, and wherein the instrument comprises a fluid transfer device comprising a programmable processor and a head configured to adhere to a pipette tip;
B) reading the identifier on the cartridge and transmitting the identity of the identifier from the instrument to an external device, the external device being external from the instrument;
C) receiving by the programmable processor of the fluid transfer device a protocol from the external device, wherein the protocol is associated with the identifier and comprises instructions for transferring the reagent to the assay unit;
D) transferring by the fluid transfer device a selected volume of the reagent to the assay unit, wherein the selected volume is provided in the protocol, and wherein the fluid transfer device is operable to transfer different volumes of the reagent into the assay unit; and
E) engaging the assay unit with the head of the fluid transfer device and transporting by the fluid transfer device the assay unit from a first location to a second location in the instrument.
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Abstract
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
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Citations
13 Claims
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1. A method for transferring a reagent to an assay unit, comprising:
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A) inserting a cartridge into an instrument, wherein the cartridge comprises i) an identifier, ii) an assay unit configured to run a chemical reaction that yields a signal indicative of an analyte, and iii) a reagent unit comprising a reagent, and wherein the instrument comprises a fluid transfer device comprising a programmable processor and a head configured to adhere to a pipette tip; B) reading the identifier on the cartridge and transmitting the identity of the identifier from the instrument to an external device, the external device being external from the instrument; C) receiving by the programmable processor of the fluid transfer device a protocol from the external device, wherein the protocol is associated with the identifier and comprises instructions for transferring the reagent to the assay unit; D) transferring by the fluid transfer device a selected volume of the reagent to the assay unit, wherein the selected volume is provided in the protocol, and wherein the fluid transfer device is operable to transfer different volumes of the reagent into the assay unit; and E) engaging the assay unit with the head of the fluid transfer device and transporting by the fluid transfer device the assay unit from a first location to a second location in the instrument. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification