Processes for making porous implantable materials
First Claim
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1. A process for forming an open celled foam suitable for implantation, the process comprising the steps of:
- combining a first composition comprising a first organic solvent and at least one extractable agent, and a second composition comprising a second organic solvent and at least one silicone matrix agent thereby forming a mixture, wherein said at least one matrix agent is less than about 40% of said mixture;
agitating said mixture thereby forming an emulsion; and
curing said emulsion thereby forming said open celled foam including a matrix of interconnected spheres;
wherein said silicone matrix agent is a high temperature vulcanizing (HTV) silicone.
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Abstract
Described herein are methods of making open celled foams including a matrix of interconnected spheres. The open celled foams are silicone based materials and can be used to coat implants, such as breast implants, and function to encourage tissue ingrowth and reduce capsular formation.
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Citations
22 Claims
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1. A process for forming an open celled foam suitable for implantation, the process comprising the steps of:
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combining a first composition comprising a first organic solvent and at least one extractable agent, and a second composition comprising a second organic solvent and at least one silicone matrix agent thereby forming a mixture, wherein said at least one matrix agent is less than about 40% of said mixture; agitating said mixture thereby forming an emulsion; and curing said emulsion thereby forming said open celled foam including a matrix of interconnected spheres; wherein said silicone matrix agent is a high temperature vulcanizing (HTV) silicone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A process for forming an open celled foam suitable for implantation, the process comprising the steps of:
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combining a first composition comprising a first organic solvent and at least one extractable agent, and a second composition comprising a second organic solvent and at least one silicone matrix agent thereby forming a mixture, wherein said at least one matrix agent is less than about 40% of said mixture; agitating said mixture thereby forming an emulsion; and curing said emulsion thereby forming said open celled foam including a matrix of interconnected spheres; wherein said at least one extractable agent is a polymer selected from the group consisting of poly siloxane, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, and combinations thereof. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A process for forming an open celled foam suitable for implantation, the process comprising the steps of:
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combining a first composition comprising a first organic solvent and at least one extractable agent, and a second composition comprising a second organic solvent and at least one silicone matrix agent thereby forming a mixture, wherein said at least one matrix agent is less than about 40% of said mixture; agitating said mixture thereby forming an emulsion; curing said emulsion thereby forming said open celled foam including a matrix of interconnected spheres; and dipping an implant into said emulsion before said curing step. - View Dependent Claims (18, 19, 20, 21, 22)
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Specification