Optical sensor configuration for ratiometric correction of glucose measurement
First Claim
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1. A sensor for detecting an analyte concentration, comprising:
- an optical fiber with proximal and distal ends;
an atraumatic tip portion with proximal and distal ends, wherein the proximal end of the atraumatic tip portion is separated from the distal end of the optical fiber, such that a gap exists between the atraumatic tip portion and the optical fiber;
a rod with proximal and distal ends, wherein the proximal end of the rod is attached to the distal end of the optical fiber, and wherein the distal end of the rod is attached to the proximal end of the atraumatic tip portion, such that the rod traverses the gap and couples the optical fiber to the atraumatic tip portion;
a chemical indicator system disposed within the gap and capable of generating an emission light signal in response to an excitation light signal, wherein the intensity of the emission light signal is related to the analyte concentration; and
a selectively permeable membrane disposed over the gap.
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Abstract
Embodiments of the invention are directed to an optical sensor for detecting glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the glucose, such that ratiometric correction of glucose measurements for artifacts in the optical system is enabled.
433 Citations
31 Claims
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1. A sensor for detecting an analyte concentration, comprising:
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an optical fiber with proximal and distal ends; an atraumatic tip portion with proximal and distal ends, wherein the proximal end of the atraumatic tip portion is separated from the distal end of the optical fiber, such that a gap exists between the atraumatic tip portion and the optical fiber; a rod with proximal and distal ends, wherein the proximal end of the rod is attached to the distal end of the optical fiber, and wherein the distal end of the rod is attached to the proximal end of the atraumatic tip portion, such that the rod traverses the gap and couples the optical fiber to the atraumatic tip portion; a chemical indicator system disposed within the gap and capable of generating an emission light signal in response to an excitation light signal, wherein the intensity of the emission light signal is related to the analyte concentration; and a selectively permeable membrane disposed over the gap. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A sensor for detecting an analyte concentration, comprising:
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an optical fiber with proximal and distal ends; an atraumatic tip portion with proximal and distal ends, wherein the proximal end of the atraumatic tip portion is separated from the distal end of the optical fiber, such that a gap exists between the atraumatic tip portion and the optical fiber; a hypotube with proximal and distal ends, wherein the proximal end of the hypotube is attached to the distal end of the optical fiber, and wherein the distal end of the hypotube is attached to the proximal end of the atraumatic tip portion, such that the hypotube traverses the gap and couples the optical fiber to the atraumatic tip portion, wherein the hypotube comprises at least one window that opens onto the gap; a chemical indicator system disposed within the gap and capable of generating an emission light signal in response to an excitation light signal, wherein the intensity of the emission light signal is related to the analyte concentration; and a selectively permeable membrane disposed over the at least one window. - View Dependent Claims (22, 23)
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24. A sensor for detecting an analyte concentration, comprising:
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an optical fiber with proximal and distal ends; an atraumatic tip portion with proximal and distal ends, wherein the proximal end of the atraumatic tip portion is separated from the distal end of the optical fiber, such that a gap exists between the atraumatic tip portion and the optical fiber; a cage connecting the optical fiber and atraumatic tip portion, wherein the optical fiber is at least partially enclosed within the cage, and wherein the cage has at least one window; a chemical indicator system disposed within the cage, wherein the chemical indicator system is adjacent the window and is separated from analyte by a selectively permeable membrane, and wherein the chemical indicator system is capable of generating an emission light signal in response to an excitation light signal, wherein the intensity of the emission light signal is related to the analyte concentration; and a reference material, wherein the reference material is configured to either reflect a portion of the excitation light signal before the excitation light signal enters the chemical indicator system or to return a second emission light signal, wherein the intensity of the second emission light signal is not related to the analyte concentration. - View Dependent Claims (25)
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26. A sensor for detecting an analyte concentration, comprising:
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an optical fiber with a proximal end and a distal end, wherein the distal end of the optical fiber comprises a glucose sensing hydrogel and wherein the glucose sensing hydrogel comprises a first fluorophore, a quencher, and at least one glucose binding moiety; a reference fiber adjacent the optical fiber having a proximal end and a distal end, wherein the distal end of the reference fiber comprises a reference material, wherein the reference material comprises a second fluorophore; a light emitting diode operably coupled to the glucose fiber and the reference fiber, wherein the light emitting diode sends an excitation light to the glucose fiber and the reference fiber; a glucose signal detector operatively coupled to the glucose fiber, wherein the glucose signal detector receives a first fluorescent light from the glucose fiber; and a reference signal detector operatively coupled to the reference fiber, wherein the reference signal detector receives a second fluorescent light from the reference fiber. - View Dependent Claims (27, 28, 29, 30, 31)
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Specification