Brain function scan system

• US 8,700,142 B2
• Filed: 11/21/2008
• Issued: 04/15/2014
• Est. Priority Date: 08/07/1997
• Status: Expired due to Fees

• Current Assignee: New York University
• Original Assignee: New York University
• Inventors: John, Erwin Roy, John, Michael Sasha
• Primary Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US12/275,395
• Publication Number:
  US 20090076407A1
• Time in Patent Office: 1,971 Days
• Field of Search: 600544-545
• US Class Current: 600/545
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/383 Somatosensory stimuli, e.g. electric stimulation
• CPC Class Codes: A61B 5/407 Evaluating the spinal cord A61B5/4896 takes precedence
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A portable EEG (electroencephalograph) instrument, especially for use in emergencies and brain assessments in physicians'"'"' offices, detects and amplifies brain waves and converts then into digital data for analysis by comparison with data from normal groups. In one embodiment, the EEG electrodes are in a headband which broadcasts the data, by radio or cellular phone, to a local receiver for re-transmission and/or analysis. In another embodiment, the subject is stimulated in two modes, i.e., aural and sensory, at two different frequencies to provide the subject'"'"'s EPs (Evoked Potentials), assessing transmission through the brainstem and thalamus.

Claims

1. A medical system for analyzing brain waves of a subject, comprising:

a first active EEG (electroencephalograph) electrode detecting a subject'"'"'s brain waves;

a stimulus generator providing to the subject sense stimuli in a plurality of stimulus modes to generate Evoked Potentials (EP), wherein the sense stimuli is delivered in multiple modalities at different prime number frequencies Fi to separate the Evoked Potentials;

a computer system receiving brain waves from the first electrode, said computer system comprising a memory unit to store reference data and a microprocessor configured to perform artifact rejection and data analysis of spontaneous EEG data and EP data, wherein the microprocessor is configured to determine, based on the data analysis, whether there is an injury to and dysfunction of at least one of the subject'"'"'s spinal cord, brain stem and brain;

a visual output coupled to the microprocessor and configured to display the determination made by the microprocessor, the display being in the form of a normal versus abnormal indication; and

a telemetric transmitter unit transmitting a result of the data analysis wirelessly to a remote receiving station for display and result storage.

2. The medical system of claim 1, further comprising an analog amplification channel connected to the active EEG.

3. The medical system of claim 2, further comprising a headgear on which the first electrode and the analog amplification channel are situated.

4. The medical system of claim 1, further comprising an analog-to-digital converter digitizing the amplified brain waves and supplying the digitized brain waves to the computer system.

5. The medical system of claim 1, wherein the data analysis is performed using Fast Fourier Transform (FFT) of narrow frequency bands, calculating power at each frequency band, and performing statistical evaluation by computing a Z-score, where Z=(N−

P)/6, wherein N is a mean value of a normative distribution, P is a current measure from the subject and 6 is a standard deviation of a control age-matched population.

6. The medical system of claim 1, wherein FFT is used to compare a power at Fi when the stimulus generator is powered on to a power at Fi when the stimulus generator is powered off to compute an F-ratio for each frequency Fi, wherein the F-ratio=Pstim/Pref, where Pstim is the power under stimulation and Pref is the power prior to stimulation.

7. The medical system of claim 1, wherein the microprocessor is further configured to perform a split-half algorithm to improve signal-to-noise ratio.

8. The medical system of claim 1, further comprising a second active EEG electrode detecting a subject'"'"'s brain waves, the computer system receiving brain waves from the second electrode.

9. The medical system of claim 1, wherein a first stimulus is adapted to be detected by a first sensory organ of the subject and a second stimulus is adapted to be detected by a second sensory organ of the subject.

10. The medical system of claim 9, wherein the first stimulus is one of a visual and an auditory stimulus.

11. The medical system of claim 9, wherein the second stimulus is one of a vibratory and an electrical pulse.