Drug delivery from electroactive molecularly imprinted polymer

• US 8,702,792 B2
• Filed: 03/22/2012
• Issued: 04/22/2014
• Est. Priority Date: 03/12/2005
• Status: Active Grant

• Current Assignee: Saint Louis University
• Original Assignee: Saint Louis University
• Inventors: Minteer, Shelley D., Ulyanova, Jenny
• Primary Examiner(s): UNDERDAHL, THANE E
• Application Number:
  US13/427,620
• Publication Number:
  US 20120197180A1
• Time in Patent Office: 761 Days
• Field of Search: 977/904, 977/906, 623/1.42
• US Class Current: 623/1.42
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: H01M 8/16 Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• CPC Class Codes: Y02E 60/50 Fuel cells

Abstract

A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.

Claims

1. A device for delivery of a chemical or biological agent comprising:

a first imprint molecule comprising said chemical or biological agent to be delivered by said device into an environment in which said device is located;

a second imprint molecule comprising an analyte present in said environment in which said device is located;

a first electroactive molecularly imprinted polymer imprinted with said first imprint molecule, said first electroactive molecularly imprinted polymer also having a plurality of first binding sites capable of binding said first imprint molecule, each of said first binding sites characterized by a binding affinity between said first binding site and said first imprint molecule; and

a second electroactive molecularly imprinted polymer imprinted with said second imprint molecule and having a plurality of second binding sites capable of binding said second imprint molecule, each of said second binding sites characterized by a certain binding affinity between said second binding site and said second imprint molecule;

wherein binding of said second imprint molecule to said second electroactive molecularly imprinted polymer creates an electric potential between said second electroactive molecularly imprinted polymer and said first electroactive molecularly imprinted polymer;

wherein said first electroactive molecularly imprinted polymer has a predetermined density of said first imprint molecules bound at said first binding sites;

wherein when a sufficient potential is produced between said second electroactive molecularly imprinted polymer and said first electroactive molecularly imprinted polymer, electrons transfer from said second electroactive molecularly imprinted polymer to said first electroactive molecularly imprinted polymer causing said binding affinity between said first binding site and said first imprint molecule to decrease so that said first imprint molecule is released from said first binding site and thereby delivered by said device into said environment, and

wherein said first electroactive molecularly imprinted polymer and said second electroactive molecularly imprinted polymer are conducting polymers.

2. The device of claim 1:

wherein said first binding sites are capable of transitioning between at least a first electroconformation and a second electroconformation;

wherein said binding affinity between said first imprint molecule and said first binding site existing in said first electroconformation is greater than said binding affinity between said first imprint molecule and said first binding site existing in said second electroconformation; and

wherein said sufficient potential produced between said second electroactive molecularly imprinted polymer and said first electroactive molecularly imprinted polymer results in said transition of said first binding site between said first electroconformation and said second electroconformation.

3. The device of claim 1:

wherein said first imprint molecule is capable of transitioning between at least a first electroconformation and a second electroconformation;

wherein said binding affinity between said first binding site and said first imprint molecule existing in said first electroconformation is greater than said binding affinity between said first binding site and said first imprint molecule existing in said second electroconformation; and

wherein said sufficient potential produced between said second electroactive molecularly imprinted polymer and said first electroactive molecularly imprinted polymer results in said transition of said first imprint molecule between said first electroconformation and said second electroconformation.

4. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is capable of undergoing a redox reaction at said binding site.

5. The device of claim 1 wherein said environment is blood within a vein or artery.

6. The device of claim 1 wherein said analyte is related to a physiological symptom or condition.

7. The device of claim 6 wherein said first imprint molecule is a drug to treat said physiological symptom or condition.

8. The device of claim 1 wherein said analyte is selected from the group consisting of:

a neurotransmitter, a hormone, an autocrine factor, a paracrine factor, a fatty acid, and an adrenocoritcal hormone.

9. The device of claim 1 wherein said analyte is selected from the group consisting of:

catecholamines, epinephrine, norepinephrine, serotonin, dopamine, NO, pyruvate, glucose, short chain alcohol, and long chain alcohol.