Bio-artificial pancreas and a procedure for preparation of same
First Claim
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1. A method for producing an implantable device for providing insulin comprising:
- (A) providing at least one implantable device for producing insulin, the device comprising;
a perforated mid-section bound at the edges thereof by a seal wherein the perforated midsection includes a pattern of perforations;
and at least one filling port designed to permit the perforated mid-section to be filled with insulin producing cells;
(B) depositing on the perforated mid-section a biologically compatible polymer network; and
(C) forming at least one immunoisolatory membrane on the perforated mid-section with a biologically compatible polymer network deposited thereon;
wherein the biologically compatible network is a nanomat formed from electrospun polyurethane nanofibers.
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Abstract
The present invention generally relates to implantable devices for producing insulin in diabetic animals and to methods of making same. Some embodiments include amphiphilic biomembranes for use in biological applications (e.g., as an alternative and/or supplemental insulin source). Some embodiments also include live insulin-producing cells contained within one or more amphiphilic membranes so as to prevent or diminish an immuno-response and/or rejection by the host.
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30 Claims
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1. A method for producing an implantable device for providing insulin comprising:
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(A) providing at least one implantable device for producing insulin, the device comprising; a perforated mid-section bound at the edges thereof by a seal wherein the perforated midsection includes a pattern of perforations; and at least one filling port designed to permit the perforated mid-section to be filled with insulin producing cells; (B) depositing on the perforated mid-section a biologically compatible polymer network; and (C) forming at least one immunoisolatory membrane on the perforated mid-section with a biologically compatible polymer network deposited thereon; wherein the biologically compatible network is a nanomat formed from electrospun polyurethane nanofibers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for producing an implantable device for providing insulin comprising:
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(a) providing at least one implantable device for producing insulin, the device comprising; a perforated mid-section bound at the edges thereof by a seal, wherein the perforated midsection includes a pattern of perforations; and at least one filling port designed to permit the perforated mid-section to be filled with insulin producing cells; (b) depositing on the perforated mid-section a biologically compatible polymer network; (c) forming at least one immunoisolatory membrane on the perforated mid-section with a biologically compatible polymer network deposited thereon; (d) implanting the device into a diabetic mammal; (e) filling the device with a suitable amount of insulin producing cells; and (f) sealing the device to yield the insulin producing device wherein the biologically compatible network is a nanomat formed from electrospun polyurethane nanofibers. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification