Electrochemical detection of silica species

• US 8,702,957 B2
• Filed: 06/29/2007
• Issued: 04/22/2014
• Est. Priority Date: 06/29/2007
• Status: Active Grant

• Current Assignee: EMD Millipore Corporation (Merck & Co., Inc.), Arizona Board of Regents (University of Arizona)
• Original Assignee: EMD Millipore Corporation (Merck & Co., Inc.), Arizona Board of Regents (University of Arizona)
• Inventors: Wang, Joseph, Dimitrakopoulos, Aristotelis, Le Ninivin, Celine, Mabic, Stephane
• Primary Examiner(s): DIETERLE, JENNIFER M
• Application Number:
  US12/666,492
• Publication Number:
  US 20100193377A1
• Time in Patent Office: 2,489 Days
• Field of Search: 204/410, 204/411, 204421-435, 204/406, 204/409, 205/775, 205/794.5, 422/68.1, 422/82.01, 435/287.1, 436/73, 436/72
• US Class Current: 205/775
• CPC Class Codes: G01N 27/48 using polarography, i.e. measuring changes in current under a slowly-varying voltage

Abstract

A systems and apparatus for measuring non-electroactive materials in liquids using electrochemical detection. A first electrical activity of a electroactive material is detected in absence of a target non-electroactive material (Step 120). A second electrical activity of the electroactive material is detected in presence of the target non-electroactive material (Step 130). A difference between the first and second electrical activities is obtained, and based on the obtained difference, a concentration of the target non-electroactive material is identified (Step 140).

Claims

1. A method comprising:

applying a voltage to a buffering solution, which comprises a molybdenum-chloranilate complex and is free of inorganic silica species;

measuring a first current associated with the molybdenum-chloranilate complex in absence of the inorganic silica species;

adding the inorganic silica species into the buffering solution;

measuring a second current associated with the molybdenum-chloranilate complex in the presence of the added inorganic silica species; and

obtaining a difference between the first current and the second current to identify a concentration of the added inorganic silica species in the buffering solution,

wherein measuring the first and second currents comprises using a working electrode comprising bismuth.

2. The method of claim 1, wherein measuring the first and second currents comprises applying an accumulation potential followed by a scanning potential.

3. The method of claim 2, wherein the applying an accumulation potential comprises applying an accumulation potential of an amplitude comprising 0.5 volts.

4. The method of claim 2, wherein the applying an accumulation potential comprises applying an accumulation potential for a time period that includes 60 seconds.

5. The method of claim 2, wherein applying a scanning potential comprises applying a scanning potential having at least one of a 25 millivolt amplitude, a step potential of 4 millivolt, and a frequency of 25 hertz.

6. The method of claim 1, wherein measuring the first and second currents comprises using a working electrode comprising a carbon-based electrode having a bismuth coating.

7. The method of claim 6, wherein measuring the first and second currents using a working electrode comprises using a screen printed bismuth electrode.

8. The method of claim 1, wherein measuring the first and second currents comprises measuring voltammetric signals.

9. The method of claim 8, wherein measuring the voltammetric signals comprises using a stripping voltammeter.

10. The method of claim 9, wherein measuring the voltammetric signals using a stripping voltammeter comprises using a disposable stripping voltammeter.

11. An apparatus for measuring non-electroactive materials in liquids, the apparatus comprising:

A. a detection device comprising

i. a container configured to at least partially hold a buffering solution in the container, the buffering solution comprising a molybdenum-chloranilate complex; and

ii. an electrically conductive member comprising bismuth at least partially submerged in the buffering solution, wherein the container, the buffering solution and the electrically conductive member are configured to measure a first current corresponding to the molybdenum-chloranilate complex in the absence of an inorganic silica species and a second current corresponding to the molybdenum-chloranilate complex in the presence of the inorganic silica species; and

B. a data processing device configured to receive the measured first and second currents from the detection device and to obtain a difference between the first current and the second current to identify a concentration of the inorganic silica species.

12. The apparatus of claim 11, wherein the electrically conductive member comprises a carbon-based electrode having a bismuth coating.

13. The apparatus of claim 11, wherein the electrically conductive member comprises a screen printed bismuth electrode.

14. The apparatus of claim 11, wherein the detection device is configured as a stripping voltammeter.

15. The apparatus of claim 14, wherein the stripping voltammeter comprises a disposable stripping voltammeter.

16. The apparatus of claim 11, wherein the detection device is configured to measure the first and second currents by applying an accumulation potential followed by a scanning potential.

17. An apparatus for measuring inorganic silica species in a liquid stream or sample using electrochemical detection, the apparatus comprising:

a flow-through detection device configured to continuously detect an inorganic silica species in a liquid stream or sample; and

a data processing device,

wherein the flow-through detection device comprises;

i. a container having an inlet port and an outlet port, the inlet port configured to receive a liquid stream or sample comprising a buffering solution and a molybdenum-chloranilate complex that will flow through the device; and

ii. a bismuth-based electrode at least partially submerged in the buffering solution, wherein the container, the buffering solution, and the bismuth-based electrode are configured to measure a first current corresponding to the molybdenum-chloranilate complex in the absence of an inorganic silica species and a second current corresponding to the molybdenum-chloranilate complex in the presence of the inorganic silica species, and

wherein the data processing device is configured to receive the measured first and second currents from the detection device and to obtain a difference between the first current and the second current to identify a concentration of the inorganic silica species.

18. The apparatus of claim 17, wherein the bismuth-based electrode is a carbon electrode having a bismuth coating.

19. The apparatus of claim 17, wherein the bismuth-based electrode is a disposable screen printed bismuth electrode.