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Compositions and method for multimodal imaging

  • US 8,703,097 B2
  • Filed: 02/10/2006
  • Issued: 04/22/2014
  • Est. Priority Date: 02/11/2005
  • Status: Active Grant
First Claim
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1. A composition for imaging of a biological tissue, said composition comprising:

  • a) two or more separate and unlinked signal modifying agents, each of said agents being specific for at least one imaging modality and each of said agents being specific for a different imaging modality; and

    b) a colloidal carrier comprising said two or more signal modifying agents wherein said carrier retains a sufficient amount of said agents for a time sufficient to acquire in vivo imaging data from each of the two or more signal modifying agents using said composition, and said colloidal carrier is a liposome comprising at least one lipid, cholesterol, and at least one pegylated lipid; and

    wherein said composition is specific for two or more imaging modalities selected from magnetic resonance imaging (MRI), X-ray, positron emission tomography (PET), computed tomography (CT), autoradiography, single-photon emission computed tomography (SPECT), fluoroscopy, optical imaging, fluorescence imaging, bioluminescence imaging and combinations thereof and each of the signal modifying agents is present at a different concentration that is sufficient to acquire in vivo imaging data from an imaging modality for which said signal modifying agent is specific, wherein said composition comprises i) a signal modifying agent specific for MRI comprising gadoteridol and a signal modifying agent specific for CT comprising iohexol, ii) a signal modifying agent specific for optical imaging comprising a fluorophore and a signal modifying agent specific for CT comprising iohexol or iii) a signal modifying agent specific for optical imaging comprising a fluorophore and a signal modifying agent specific for MRI comprising gadoteridol.

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