Implantable device having a coating comprising carrageenan and a biostable polymer
First Claim
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1. An implantable device, comprising a polymeric matrix, said matrix disposed over essentially the entire exposed surface of the implantable device, said matrix consisting of a water dissolvable polymer or material, a biostable polymer, and one or more bioactive agents;
- the water dissolvable polymer or material being selected from the group consisting of kappa carrageenan, iota carrageenan, and lambda carrageenan; and
the biostable polymer being selected from the group consisting of polyethers, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers, polyvinyl chloride, polyvinyl ethers, polyvinyl methyl ether, polyvinylidene chloride, polyvinyl ketones, polyvinyl alcohol, polyvinyl acetate, acrylonitrile-styrene copolymers, ABS resins, ethylene-vinyl acetate copolymers, polyamides, Nylon 66, co-polyamides, poly ether or ester block amide, polyoxymethylenes, polyimides, poly(propylene fumarate), poly(n-butyl methacrylate), poly(sec-butyl methacrylate), poly(isobutyl methacrylate), poly(tert-butyl methacrylate), poly(n-propyl methacrylate), poly(isopropyl methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate), epoxy resins, polyurethanes, rayon, rayon-triacetate, polyethers, poly(ethylene glycol), polyalkylene oxides, poly(ethylene oxide), poly(propylene oxide), polymers and co-polymers of choline or phosphoryl choline bearing monomers, polymers and co-polymers of hydroxyl bearing monomers, 2-hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxypropyl methacrylamide, poly(ethylene glycol)-acrylate, poly(ethylene glycol)-methacrylate, copolymers and polymers of 2-methacryloyloxyethylphosphorylcholine and n-vinyl pyrrolidone, alkoxymethacrylate, alkoxyacrylate, 3-trimethylsilylpropyl methacrylate, poly(styrene-isoprene-styrene)-poly(ethylene glycol), polystyrene-poly(ethylene glycol), polyisobutylene-poly(ethylene glycol), poly(methyl methacrylate)-poly(ethylene glycol), polydimethylsiloxane-co-poly(ethylene glycol), polypropylene oxide-co-polyethylene glycol surfactants, poly(tetramethylene glycol), and hydroxy functional poly(vinyl pyrrolidone).
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Abstract
The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.
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Citations
10 Claims
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1. An implantable device, comprising a polymeric matrix, said matrix disposed over essentially the entire exposed surface of the implantable device, said matrix consisting of a water dissolvable polymer or material, a biostable polymer, and one or more bioactive agents;
- the water dissolvable polymer or material being selected from the group consisting of kappa carrageenan, iota carrageenan, and lambda carrageenan; and
the biostable polymer being selected from the group consisting of polyethers, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers, polyvinyl chloride, polyvinyl ethers, polyvinyl methyl ether, polyvinylidene chloride, polyvinyl ketones, polyvinyl alcohol, polyvinyl acetate, acrylonitrile-styrene copolymers, ABS resins, ethylene-vinyl acetate copolymers, polyamides, Nylon 66, co-polyamides, poly ether or ester block amide, polyoxymethylenes, polyimides, poly(propylene fumarate), poly(n-butyl methacrylate), poly(sec-butyl methacrylate), poly(isobutyl methacrylate), poly(tert-butyl methacrylate), poly(n-propyl methacrylate), poly(isopropyl methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate), epoxy resins, polyurethanes, rayon, rayon-triacetate, polyethers, poly(ethylene glycol), polyalkylene oxides, poly(ethylene oxide), poly(propylene oxide), polymers and co-polymers of choline or phosphoryl choline bearing monomers, polymers and co-polymers of hydroxyl bearing monomers, 2-hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxypropyl methacrylamide, poly(ethylene glycol)-acrylate, poly(ethylene glycol)-methacrylate, copolymers and polymers of 2-methacryloyloxyethylphosphorylcholine and n-vinyl pyrrolidone, alkoxymethacrylate, alkoxyacrylate, 3-trimethylsilylpropyl methacrylate, poly(styrene-isoprene-styrene)-poly(ethylene glycol), polystyrene-poly(ethylene glycol), polyisobutylene-poly(ethylene glycol), poly(methyl methacrylate)-poly(ethylene glycol), polydimethylsiloxane-co-poly(ethylene glycol), polypropylene oxide-co-polyethylene glycol surfactants, poly(tetramethylene glycol), and hydroxy functional poly(vinyl pyrrolidone). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- the water dissolvable polymer or material being selected from the group consisting of kappa carrageenan, iota carrageenan, and lambda carrageenan; and
Specification