Inhibition of neovascularization by cerium oxide nanoparticles
First Claim
1. A method of inhibiting, reducing and/or reversing neovascularization associated with a pathological ocular condition in a mammalian subject, the method comprising the steps of:
- administering a therapeutically effective amount of a pharmaceutical composition to a mammalian subject exhibiting neovascularization associated with a pathological ocular condition, the pharmaceutical composition comprising cerium oxide nanoparticles and a pharmaceutically acceptable carrier; and
reducing at least one of (a) at least one vascular anomaly, (b) the number of illicit neovessels, (c) the rate of retinal neovascularization, and (d) the rate of proliferation of neovascular tissue in the eye of the mammalian subject upon administration of the cerium oxide nanoparticles present in the pharmaceutical composition.
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Abstract
The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
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Citations
10 Claims
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1. A method of inhibiting, reducing and/or reversing neovascularization associated with a pathological ocular condition in a mammalian subject, the method comprising the steps of:
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administering a therapeutically effective amount of a pharmaceutical composition to a mammalian subject exhibiting neovascularization associated with a pathological ocular condition, the pharmaceutical composition comprising cerium oxide nanoparticles and a pharmaceutically acceptable carrier; and reducing at least one of (a) at least one vascular anomaly, (b) the number of illicit neovessels, (c) the rate of retinal neovascularization, and (d) the rate of proliferation of neovascular tissue in the eye of the mammalian subject upon administration of the cerium oxide nanoparticles present in the pharmaceutical composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of treating a mammalian subject having at least one neovascular lesion in an eye thereof, the method comprising the steps of:
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administering a therapeutically effective amount of a pharmaceutical composition to the eye of the mammalian subject, the pharmaceutical composition comprising cerium oxide nanoparticles and a pharmaceutically acceptable carrier, wherein the cerium oxide nanoparticles have a size in a range of from about 1 nanometer in diameter to about 10 nanometers in diameter and are present in the pharmaceutical composition at a concentration in a range of from about 1 nM to about 1.0 mM; and reducing the at least one neovascular lesion in the eye of the mammalian subject to 50% or less of that observed in the absence of administration of the pharmaceutical composition, and wherein the at least one neovascular lesion is at least one of a retinal neovascular lesion and a choroidal neovascular lesion.
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Specification