Hyperpolarization methods, systems and compositions

• US 8,703,201 B2
• Filed: 12/22/2011
• Issued: 04/22/2014
• Est. Priority Date: 02/21/2006
• Status: Expired due to Fees

• Current Assignee: Millikelvin Technologies LLC
• Original Assignee: Millikelvin Technologies LLC
• Inventors: Belzer, Avrum, Kalechofsky, Neal
• Primary Examiner(s): Krass, Frederick
• Assistant Examiner(s): Shomer, Isaac
• Application Number:
  US13/335,076
• Publication Number:
  US 20120114851A1
• Time in Patent Office: 852 Days
• Field of Search: None
• US Class Current: 424/489
• CPC Class Codes: A61K 49/1806 Suspensions, emulsions, colloids, dispersions
• CPC Class Codes: A61K 49/1815 compo-inhalant, e.g. breath tests

Abstract

The disclosure provides various methods and systems for providing hyperpolarized materials as well as the hyperpolarized materials so provided. In addition, methods of providing hyperpolarized materials, such as agents, to end users from a remote location are also provided.

Claims

1. A method of providing a suspension including a hyperpolarized beneficial agent, comprising:

a) forming a plurality of capsules, each capsule including a core material comprising at least one material that is solid or liquid at standard conditions, surrounded by an encapsulating layer, wherein the encapsulating layer is porous to the passage of helium gas and excludes the passage of oxygen or other depolarizing elements;

b) hyperpolarizing at least a portion of the core material to form a hyperpolarized beneficial agent, wherein hyperpolarization comprises the step of exposing the capsules to helium; and

c) dispersing the hyperpolarized beneficial agent in a fluid medium.

2. The method of claim 1, wherein the encapsulating layer excludes the passage of oxygen.

3. The method of claim 1, wherein the fluid medium includes a physiologically tolerable liquid.

4. The method of claim 1, wherein the fluid medium includes a physiologically tolerable gas.

5. The method of claim 1, wherein the core material includes material that is a solid at standard conditions.

6. The method of claim 1, wherein the core material includes material that is a liquid at standard conditions.

7. The method of claim 1, wherein the core material includes ¹³C.

8. The method of claim 1, wherein the encapsulating layer includes solid material.

9. The method of claim 1, wherein the encapsulating layer includes a liposome having a lipid bilayer.

10. The method of claim 1, further comprising the step of forming an image of a region of interest where the hyperpolarized beneficial agent is present, wherein the image is formed by magnetic resonance imaging.

11. The method of claim 1, wherein the core material includes hyperpolarized pyruvate, and the method further comprises delivering the beneficial agent including the hyperpolarized pyruvate to a target cell, and detecting a hyperpolarized metabolite formed by the target cell from the hyperpolarized pyruvate, wherein the hyperpolarized metabolite is detected using magnetic resonance.

12. The method of claim 1, wherein the encapsulating layer includes a biologically derived medium.

13. The method of claim 1, wherein the encapsulating layer substantially maintains its structural integrity at temperatures below 100K.

14. The method of claim 1, wherein the capsules have an average diameter less than about 100 microns.

15. The method of claim 1, wherein the capsules have an average diameter less than about 10 microns.

16. The method of claim 1, wherein the capsules further include a functional element disposed proximate the encapsulating layer.

17. The method of claim 16, wherein the functional element includes a protein.

18. The method of claim 1, wherein the encapsulated material is transported from a first location where it is hyperpolarized to a second location remote from the first location in a storage vessel including an insulated Dewar disposed in a magnetic field created by the storage vessel.

19. The method of claim 1, wherein hyperpolarization is accomplished using a brute force environment in conjunction with a quantum relaxation switch employing ³He.

20. The method of claim 19, wherein the hyperpolarizing step includes decreasing the temperature of the core material to a temperature below about 100K.

21. The method of claim 19, wherein the hyperpolarizing step includes decreasing the temperature of the core material to a temperature below about 10K.

22. The method of claim 19, wherein the hyperpolarizing step includes decreasing the temperature of the core material to a temperature below about 1K.