Method comprising co-crosslinking polyaniline, polymer acid and redox enzyme to produce polymeric matrix
First Claim
1. A method for producing a crosslinked polymeric matrix, the method comprising co-crosslinking a polyaniline, a polymer acid and a redox enzyme with a crosslinker to produce the crosslinked polymeric matrix.
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Abstract
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
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17 Claims
- 1. A method for producing a crosslinked polymeric matrix, the method comprising co-crosslinking a polyaniline, a polymer acid and a redox enzyme with a crosslinker to produce the crosslinked polymeric matrix.
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