Antiadhesive material

• US 8,703,627 B2
• Filed: 06/12/2002
• Issued: 04/22/2014
• Est. Priority Date: 06/15/2001
• Status: Expired due to Fees

• Current Assignee: Gunze Limited, JMS Company Limited
• Original Assignee: Gunze Limited, JMS Company Limited
• Inventors: Matsuda, Shojiro, Tanaka, Yoshimi, Ikada, Yoshito
• Primary Examiner(s): PIZIALI, ANDREW T
• Application Number:
  US10/480,744
• Publication Number:
  US 20040137179A1
• Time in Patent Office: 4,332 Days
• Field of Search: 606/228, 606/230, 606/231, 442/123, 442/286, 442/394, 442/312, 428/36.1, 424/426, 424/444
• US Class Current: 442/123
• CPC Class Codes: A61L 31/045 Gelatin
• CPC Class Codes: A61L 31/129 containing macromolecular fillers
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: Y10T 428/1362 Textile, fabric, cloth, or pile containing [e.g., web, net, woven, knitted, mesh, nonwoven, matted, etc.]
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]
• CPC Class Codes: Y10T 428/31786 Of polyester [e.g., alkyd, etc.]
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
• CPC Class Codes: Y10T 442/45 Knit fabric is characterized by a particular or differential knit pattern other than open knit fabric or a fabric in which the strand denier is specified

Abstract

An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so that the reinforcing material 12 is impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin film 11 and the reinforcing material 12 are integrated is obtained. The reinforcing material 12 preferably is arranged in a portion of the gelatin film 11 to be subjected to suturing, and preferably is arranged along a periphery of the gelatin film 11. The gelatin film 11 preferably is a cross-linked gelatin film, and the reinforcing material 12 preferably is a nonwoven fabric.

Claims

1. An antiadhesive material comprising a gelatin film, the antiadhesive material further comprising:

a reinforcing material that is made of a biodegradable polymer other than collagen and is arranged in the gelatin film,

wherein the reinforcing material is a fabric body having a density in a range of 5 g/m² to 45 g/m² and a yarn threading tension in a range of 0.210 N to 200 N, and

wherein the biodegradable polymer is at least one polymer selected from the group consisting of polylactic acid, lactic acid-caprolactone copolymer, polyglycolic acid, lactic acid-glycolic acid copolymer, lactic acid-ethylene glycol copolymer, polydioxanon, glycolic acid-caprolactone copolymer, glycolic acid-trimethylene carbonate copolymer, glycolic acid-dioxanon-trimethylene carbonate copolymer, chitin, chitosan, and fibrin,

wherein the reinforcing material and the gelatin film are integrated due to gelation of gelatin that has intruded entirely in an internal part of the reinforcing material, and

wherein the fabric body is a knitted fabric that is a twin loop knit fabric having the twin loop knit as shown in FIG. 7.

2. The antiadhesive material according to claim 1, wherein the antiadhesive material is in a sheet form or in a cylindrical form.

3. The antiadhesive material according to claim 1, wherein the reinforcing material is arranged in a portion of the gelatin film to be subjected to suturing.

4. The antiadhesive material according to claim 1, wherein the reinforcing material is arranged along a periphery of the gelatin film.

5. The antiadhesive material according to claim 1, wherein the fabric body is integrated with a nonwoven fabric to form a complex.

6. The antiadhesive material according to claim 5, wherein the nonwoven fabric is manufactured by at least one method selected from the group consisting of melt blowing, needle punching, spunbonding, and flash spinning.

7. The antiadhesive material according to claim 6, wherein the nonwoven fabric is processed by hot pressing.

8. The antiadhesive material according to claim 1, wherein the fabric body has a thickness in a range of 10 μ

m to 1000 μ

m.

9. The antiadhesive material according to claim 1, wherein the fabric body has a yarn threading tension in a range of 0.3 N to 200 N.

10. The antiadhesive material according to claim 1, wherein the biodegradable polymer is at least one polymer selected from the group consisting of polylactic acid, lactic acid-caprolactone copolymer, and polyglycolic acid.

11. The antiadhesive material according to claim 10, wherein a molar ratio (A:

B) of lactide (A) and caprolactone (B) in the lactic acid-caprolactone copolymer is in a range of 85;

15 to 40;

60.

12. The antiadhesive material according to claim 1, wherein the reinforcing material is subjected to a hydrophilicity imparting treatment.

13. The antiadhesive material according to claim 12, wherein the hydrophilicity imparting treatment is at least one treatment selected from the group consisting of plasma treatment, glow discharge treatment, corona discharge treatment, ozone treatment, graft treatment, coating, chemical treatment, and ultraviolet irradiation.

14. The antiadhesive material according to claim 1, wherein the gelatin film is a cross-linked film.

15. The antiadhesive material according to claim 14, wherein the gelatin film is cross-linked by at least one method selected from the group consisting of ultraviolet treatment, heat treatment, and chemical cross-linking agent treatment.

16. The antiadhesive material according to claim 14, wherein the gelatin film is cross-linked under conditions of an ultraviolet lamp of 4 W to 40 W, an irradiation time of 0.1 hour to 100 hours, and an irradiation distance of 5 cm to 100 cm.

17. The antiadhesive material according to claim 1, wherein a time of presence of the gelatin film in a living body is in a range of 12 hours to 90 days.

18. The antiadhesive material according to claim 1, wherein the gelatin film has a thickness in a range of 20 μ

m to 2000 μ

m.

19. The antiadhesive material according to claim 1, wherein a concentration of endotoxin contained in the gelatin is not more than 200 EU/g.

20. The antiadhesive material according to claim 1, wherein the knitted fabric is a piece of knitted fabric, and the piece of knitted fabric forms a complex with two pieces of non-woven fabric, in which the piece of knitted fabric is interposed between the two pieces of nonwoven fabric.